PNB 2265 Chapter Notes - Chapter 1: Hemoglobin, Porphyrin, Blood Doping
27 Jan 2017
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Blood= CT
Regenerate on regular basis
Transport gases, nutrients, hormones body needs to function
Centrifuge: separates blood into liquid and cellular components
Plasma: 55% of blood, mostly water, protein and other dissolved solutes such as urea,
salts and organic nutrients
Buffy layer: gray/white middle, platelets and WBCs (leukocytes)
RBCs: bottom layer, erythrocytes, 44% of blood
Buffy layer and RBCs: formed elements (contain broken off fragments of larger cells)
WBCs: help initiate immune responses and defend body against pathogens
WBCs: 1.5-3X larger than RBCs
o Motile, flexible, most found in body tissues
o 5 different types
o Neutrophils Lymphocytes Monocytes Eosinophils Basophils
o Never Let Monkeys Eat Bananas! (most abundant least abundant
View components on blood smear
Small drop of blood on one slide, put second slide on top to smear
Leukocytes
o Granulocytes
Neutrophil
Most abundant WBC
Multi-lobe nuclei (as many as 5 interconnected by strands)
Poly morpho nuclear
Eosinophil
Red/pink granules in cytoplasm
Bi-lobed nuclei (2 lobes interconnected by strand)
Basophil
Least abundant
Bi-lobed nuclei
Blue/violet granules
o Agranulocytes (much smaller granules in cytoplasm)
Lymphocyte
Large round nuclei
Monocyte
Kidney, C shaped nuclei
o Presence or absence of visible granules
Eosinophilia: allergic rxn or parasitic infection
Sickle Cell Anemia: shape of RBC, sickled shape not biconcave
o Inherited disease cause by single point mutation in gene for hemoglobin beta
change
o Change in intracellular protein
o Less capacity to carry oxygen
o More likely to get stuck in vessels
find more resources at oneclass.com
find more resources at oneclass.com
Document Summary
Transport gases, nutrients, hormones body needs to function. Centrifuge: separates blood into liquid and cellular components. Plasma: 55% of blood, mostly water, protein and other dissolved solutes such as urea, salts and organic nutrients. Buffy layer: gray/white middle, platelets and wbcs (leukocytes) Rbcs: bottom layer, erythrocytes, 44% of blood. Buffy layer and rbcs: formed elements (contain broken off fragments of larger cells) Wbcs: help initiate immune responses and defend body against pathogens. Wbcs: 1. 5-3x larger than rbcs: motile, flexible, most found in body tissues, 5 different types, neutrophils lymphocytes monocytes eosinophils basophils, never let monkeys eat bananas! (most abundant least abundant. Small drop of blood on one slide, put second slide on top to smear. Multi-lobe nuclei (as many as 5 interconnected by strands) Bi-lobed nuclei (2 lobes interconnected by strand) Blue/violet granules: agranulocytes (much smaller granules in cytoplasm) Kidney, c shaped nuclei: presence or absence of visible granules. Sickle cell anemia: shape of rbc, sickled shape not biconcave.
