BCH 4024 Chapter Notes - Chapter 16-27: C-Terminus, Enolase, Pyruvic Acid
20 Oct 2015
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16: protein composition is lowest (20%) in the myelin sheath and most (70%) in the inner mitochondrial membrane. Lipid portion of membrane is 3nm (30a) thick: takes 6-7 turns for alpha helix to go through membrane. Neutral lipids and glycolipids on exterior leaflet. Fatty acyl chains in interior of membrane to form fluid hydrophobic region. Integral membrane proteins- only removable by hydrophobic agents: ex: glycophorin- transmembrane alpha helices. Carboxyl terminus inside cell: peripheral membrane proteins- released by interfering with charge/h bonding. Associated through electrostatic interactions: amphitropic proteins- in cytosol and membrane (ex: lipid anchors, membrane protein classification, type i- single tm helix, amino terminus outside, type ii- single tm helix, carbonyl terminal outside, type iii- multiple tm helices glycophorin. Bacteriorhodopsin- light driven protein pump of bacterium h. salinarum. Higher the number, the more hydrophobic: since negatively charged lipids on inner leaflet, positively charged membrane proteins on inside (lys,
