NURSE-3111 Chapter Notes - Chapter 18: Calcium Channel, Ejection Fraction, Cardiac Output
Document Summary
What are the therapeutic uses: essential hypertension. Reduce the risk of acute hypertension: reversal of toxicity from alpha-1 agonist. Reversal of htn from alpha 1 agonists: benign prostatic hyperplasia. Helps counteract the blockage brought on by prostate enlargement: pheochromocytoma. Treatment of htn before surgery if it is operable. What are the likely adverse effects: orthostatic hypotension. Caused by blockade of alpha1 receptors on veins: reflex tachycardia. Alpha-adrenergic antagonists can increase the heart rate by triggering the baroreceptor reflex. Vasodilation causes a decrease in bp: inhibition of ejaculation. Caused by blockade of alpha1 receptors in male sex organs. Alpha-1 activation is key to this process. How does it do it: a competitive antagonist that produces selective blockade of alpha1-adrenergic receptors, selective alpha1 blockade. Dilation of vessels (arterioles and veins: bph. Relaxation of smooth muscle in the bladder neck (trigone and sphincter)
