BCMB 311 Chapter Notes - Chapter 13: Tumor Necrosis Factor Superfamily, Death Domain, Fas Receptor
1 Oct 2016
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Aneuploidy - an abnormal number of chromosomes, commonly caused by errors in dna replication, dna repair, or mitosis. Apoptosome - the large quaternary protein structure formed in the process of apoptosis. Apoptotic bodies - cell fragments produced as a result of apoptosis. Apoptotic protease activating factor-1 (apaf-1) - a cytoplasmic protein which forms the central hubs in the apoptosis regulatory network. Atm - a serine-theonine protein kinase that is recruited and activated by dna double-strand breaks initiating the activation of the dna damage checkpoint, leading to cell cycle arrest, dna repair, or apoptosis. Atr - an enzyme encoded by the atr gene that is a serine/threonine-specific protein kinase involved in sensing dna damage and activating the dna damage checkpoint, leading to cell cycle arrest. Autoproteolysis - the degradation of a protein by intramolecular digestion. Bcl homology (bh) domains - conserved motifs (bh1, bh2, bh3, and bh4) that are characteristics homologs present in the bcl-2 family.
