PSB 3444 Lecture Notes - Lecture 12: Mesolimbic Pathway, Neuromuscular Junction, Genetic Predisposition
23 Jul 2018
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Document Summary
Clinical term for when we call someone crazy . Traits that are abnormally present in psychosis. Anything you can add to a person"s personality that makes them seem. Hypoactivity at cortical dopamine synapses and dysfunction of glutamate transmission. These are crippling because they take something away from your personality. Inability to initiate and participate in goal oriented activities. 1% of the world population have schizophrenia. Genetic predisposition but not directly related to genetics there are environmental influences. 10x higher chance of developing schizophrenia if family member has it. 50x higher chance of developing schizophrenia if identical twin has it. Ventricles in brain are twice as large. All antipsychotics at the time were dopamine antagonist. Due to studies of ma psychosis, which present symptoms similar to schizophrenia and is due to increased dopamine. Positive schizophrenic symptoms results from increased dopamine in the mesolimbic pathway. Negative schizophrenic symptoms results from a lack of dopamine in the mesocortical pathway.
