IMED3001 Study Guide - Midterm Guide: Macula Densa, Juxtaglomerular Apparatus, Aspartic Protease
9 Jan 2021
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The renin angiotensin aldosterone system (raas) regulates the body"s water and salt balance, affects vascular tone, intravascular volume/ venous pressures and blood pressure. Main role is to convert angiotensinogen to angiotensin i. Secretion is stimulated by intravascular volume depletion or what the kidneys think is reduced perfusion. Reduced sodium presentation to the macula densa. (in hf patients placed on salt and fluid restriction and/or treated with diuretics) Activation of baroreceptors in the renal vascular bed by reduction in renal blood flow with sympathetic nervous activation from beta1- adrenergic stimulation of the juxtaglomerular apparatus. Aldosterone leads to salt and h2o retention by the kidneys, elevating bp. Aldosterone results in an increase of the cardiac extracellular matrix. Administration of a mineralocorticoid receptor antagonist is associated with. An improvement in myocardial diastolic function, and. Reduction in the concentration of circulating biomarkers that reflect the collagen turnover associated with myocardial fibrosis 1. Renin cleaves angiotensinogen, produced by the liver, to yield angiotensin i.
