LIFESCI 7B Chapter Notes - Chapter 14.1: Replica Plating, P53, Somatic Cell
7 Nov 2017
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Chapter 14. 1: the rate & nature of mutations. Damage: reactive molecules produced during metabolism, chemicals in the environment, radiation of various types (x-rays & ultraviolet) Spontaneous: occurring in the absence of any assignable cause; most mutations are spontaneous. For individual nucleotides, mutation is a rare event. Hotspots: a site in the genome that is especially mutable. Germ cell: the reproductive cells that produce sperm or eggs and the cells that give rise to them. Somatic cell: a nonreproductive cell, the most common type of cell in the body. Across the genome as a whole, mutation is common. The rate of mutation per genome per generation depends on the size and cell division per generation. Number of mutations in male germ cells goes up as they age. Number of mutation in female germ cells remains constant with their age. Only germ-line mutations are transmitted to progeny course of time.
