BIOL-242 Lecture Notes - Lecture 56: Glycogen, Lateral Hypothalamus, Bloodborne

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Bond energy released from food must equal total energy output. Energy intake = energy liberated during food oxidation. Used to do work (driven by atp) Nearly all energy from food eventually converted to heat - cannot be used to do work. If energy intake = energy output weight stable. If not equal gain or loss of weight. Body mass index (bmi) = wt (lb) 705/height in (inches)2. Considered overweight if bmi 25 to 30. Considered obese if bmi greater than 30. Higher incidence of atherosclerosis, type 2 diabetes mellitus, hypertension, heart disease, and osteoarthritis. More adults and children overweight than 20 years ago. Arcuate nucleus (arc), lateral hypothalamic area (lha), ventromedial nucleus (vmn) of hypothalamus. Some arc neurons neuropeptide y (npy) and agouti-related peptides enhance appetite. Other arc neurons pro-opiomelanocortin (pomc) and cocaine-/amphetamine-regulated transcript (cart) suppress appetite. Bloodborne signals related to body energy stores. To lesser extent, body temperature and psychological factors. Operate through brain thermoreceptors, chemoreceptors, and others.

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