BIOL 3327 Lecture Notes - Lecture 46: Optic Neuritis, Amiodarone, Ibutilide
15 Jul 2020
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Class iii drugs (k+ channel blockers) therapeutic notes. Biggest effect: blocks voltage-gated k+ channel (class iii) Noncompetitive antagonist at beta receptors (class ii) Inhibits na+ channels and reduces pacemaker automaticity (class i) A lot of interactions with other drugs. Potent blockade of beta1 receptors, but it has the lowest side effect profile so it"s used in pediatric arrhythmias. Black box warnings (basically on all antiarrhythmics) 50% of patients usually have some kind of adverse effect, severe enough to discontinue use. Biggest being pulmonary toxicity, causing some type of fibrosis. Iodides are part of the molecule which has some similarities to the thyroxine hormone, t4. Amiodarone will inhibit the peripheral conversion of t4 to t3. which will have impacts if you have a patient taking levothyroxine. It can also result in a blue-green discoloration in patients because the iodine is deposited in the skin. Cardiovascular side effects: peripheral vasodilation, which has to do with the.
