CHM 205 Lecture Notes - Lecture 3: Ethyl Acetate, Hexane, Petroleum Ether

• School: University of Miami
• Department: Chemistry
• Course: CHM 205
• Professor: Eve T M

Document Summary

Part a: tlc analysis of ortho-hydroxyacetophenone and para- Part b: tlc analysis of analgesic components and an unknown mixture. Determine the components present in an unknown mixture described. The unknown may contain one or any combination of 2 or 3 of the following components: acetylsalicylic acid, acetaminophen, caffeine, and ibuprofen. Chromatography technique used to separate mixtures of compounds for analysis, quantification or purification. Mixture of compounds is dissolved in a liquid. Method depends on the differential adsorbities of the substances to be separated between the 2 phases. A compound with strong interaction will move slower. A compound with weak interaction will move faster. Solid-liquid (column, thin layer, paper, high-performance liquid hplc) Thin layer chromatography uses a thin layer of adsorbent material (silica gel) bound to a solid support (glass, plastic, aluminum sheet). Silica gel is a form of sio2 that is porous and therefore has a large surface area.