All Educational Materials for IMM250H1 at University of Toronto St. George (UTSG)

Lecture 1 - general overview of immune system. Recognize, attack, destroy foreign entities that can endanger our health. Have to adapt to both types of

Lecture 1: the i(cid:373)(cid:373)u(cid:374)e syste(cid:373) fro(cid:373) historical to (cid:373)oder(cid:374) perspectives. Louis pasteur: realized he

Lecture #1: a very short intro to the history of immunology. One particular event in history sheds light on the extreme usefulness of the study of immu

The purpose of the innate immune system is to recognize the pathogen and react to the pathogen. Viruses carry around genetic material that infect a cel

Imm250 lecture 1: the immune system from historical to modern perspectives. I. e. malaria, passed by mosquitos: must adapt to the different types of ho

Imm250 lecture 1: the immune system from historical to modern perspectives. I. e. malaria, passed by mosquitos: must adapt to the different types of ho

The purpose of the innate immune system is to recognize the pathogen and react to the pathogen. Viruses carry around genetic material that infect a cel

Lecture 1: the i(cid:373)(cid:373)u(cid:374)e syste(cid:373) fro(cid:373) historical to (cid:373)oder(cid:374) perspectives. Louis pasteur: realized he

Innate denotes a property of some thing or action which is essential and specific to that thing or action, and which is wholly independent of any other

After completing this exam, you may not take the exam paper with you. This test consists of a total of 40 multiple-choice questions, and is worth 30% o

Microbes are everywhere, in us around us. Pathogen means that the microbes are able to mate snd start to replicate inside and create disease. The immun

Some more on nlrp (nod-like receptor proteins): recall that they are cytosolic proteins found in host cells that recognize danger associated molecular

Lecture #1: a very short intro to the history of immunology. One particular event in history sheds light on the extreme usefulness of the study of immu

Overview of the immune response: two major groups of defences mechanisms. Skin & mucous membranes: rapidly regenerating surfaces, peristaltic movement,

Black death/ bubonic plague: responsible for 30 60% of european deaths from 1350 1400. Vector an organism that carries a causative agent for infection:

Lecture 1 the immune system: a historical perspective. The black death (bubonic plague) is one of the deadliest pandemics in human history: responsible

Lecture 5 - dr. tamminen (start of adaptive immune system- special features) There are innate cells (inborn, unchanging) and adaptive cells (imrives ov

Imm250 lecture 1: the immune system from historical to modern perspectives. I. e. malaria, passed by mosquitos: must adapt to the different types of ho

The mucosal and skin surfaces in our bodies are closely in contact with the external environment as an external protection against infection. Mucosal s

Requirements for infectious disease a pathogen is transmitted from some type of reservoir such as a diseased animal. Not all microbes will cause diseas

Black death: bites from rodent fleas/handling infected rodent. People who recovered from illness better at treating sick people. It was eventually gone

Priming: naive lymphocyte activated: antigen binding, cell to cell contact, cytokines. Na ve cells: lymphocytes that haven"t been activated by antigen.

In contrast, t cell maturation occurs in the thymus: both the bone marrow and thymus are considered primary lymphoid organs because they are the sites

Released by one cell, soluble proteins, bind to receptors. Interferons: chemokines: il-1b, il-6, il-18, and tnf, growth factors. Monitors leukocyte exi

Commensal microbes - our microbiome , vastly colonize us and perform important metabolic and protective functions for us. Function of the immune system

2. 1. 1 types of pathogens and mechanisms of pathogenicity. Four major types of pathogens: viruses, bacteria, fungi, parasites (protozoan parasites, he

7. 1 the germinal center: a place for b cell di erentiation. Some cells leave secondary lymphoid tissues to site of in ammation. Some move towards foll

Gram-stain: gram positive (violet) more peptidoglycan, and lipoteichoic acid, gram negative (pink) peptidoglycan is between outer/inner layers, much th

Immune system the tissues, cells and molecules involved in protecting the host and responding to foreign antigens primary defence against pathogens. Va

Lecture #1: a very short intro to the history of immunology. One particular event in history sheds light on the extreme usefulness of the study of immu

Imm250 lecture 1: the immune system from historical to modern perspectives. I. e. malaria, passed by mosquitos: must adapt to the different types of ho

After completing this exam, you may not take the exam paper with you. This test consists of a total of 30 multiple choice questions, and is worth 30% o

Detection system that targets: broadly conserved microbial molecules called pathogen associated molecular patterns (pamps): lps, peptidoglycan , danger

After completing this exam, you may not take the exam paper with you. This test consists of a total of 30 multiple choice questions, and is worth 30% o

Lecture 1 - the immune system, a historical perspective. Immunology: the study of the immune system: the immune system: a system if cells, tissues and

Multimeric proteins bind to sugars on cell surface. Myd-88 binds (or trif binds) nf b (or irf) transcription factors cytokine & interferon. Detected by

Lecture 1: the i(cid:373)(cid:373)u(cid:374)e syste(cid:373) fro(cid:373) historical to (cid:373)oder(cid:374) perspectives. Louis pasteur: realized he

Systemic in ammatory response syndrome (sirs: full body reaction to infectious trigger. Usually pneumonia, urinary tract infections, skin, gut: high lp

Chapter 8: ensure tolerance to food antigens and microbiota + respond to pathogens, skin and mucosal surfaces - portals of entry for microbes, barriers

Successful: smallpox eradication ~ who campaign 1979, polio ~ next who target, measles, mumps, rubella, chicken pox, human papilloma virus (hpv) 70% of

Mucosal system need to determine whether antigen id innocuous or harmful physiologic information (low level) that. System activates dendritic cells tri

Lecture 9 - emerging influenza variants and the case for improved vaccines. Flu is an acute upper respiratory infection. Fever, cough and systemic symp

Lecture 5 - generation of the adaptive immune response. Central tolerance process for self reactive lymphocytes mature. Mature: encountered antigen, un

Lecture 4 - the acute inflammatory response: cellular and humoral mediators of innate defense. Phagocytosis, cytokine, apc (bridge between adaptive and

Lecture 1 - the immune system: from historical to modern perspectives. A system of tissue, cells and soluble factors that recognize, attack and destroy

Lecture 3 - innate immunity: first line of defense. Pathogens that are too big to be ingested, release granules. Property: encoded in pathogenicity isl