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All Educational Materials for Pathology 3500 at Western University

Introduction To Human Pathology

Pathology 3500 Lecture Notes - Lecture 38: Substantia Nigra, Gear, Presenilin
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Alzheimers Pathology Gross Space between the gyri is enlarged Tangles Deposit of abnormal proteins within the terminal process of neurons Makes it difficult for axons to connect Alzheimers Pathogenesis 80 are sporadic (no ...

Pathology
Pathology 3500
Jessica Shepherd
Pathology 3500 Lecture Notes - Lecture 40: Metabolic Bone Disease, Osteomalacia, Osteopenia
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Rickets and Osteomalacia Rickets: children, osteomalacia: adults Decrease or failure of minzation of bone Show up as decrease bone density on an xray thi is osteopenia) Main cause is Inadequate vitamin D Dietary insufficie...

Pathology
Pathology 3500
Jessica Shepherd
Pathology 3500 Lecture Notes - Lecture 37: Embolization, Thrombosis, Perfusion
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Vascular Disease Stroke Rapid onset neurological deficit Tends to improve over time (variable degree) Why is there recovery of function over time after a stroke? Reperfusion A soft clot can break apart on its own or if the...

Pathology
Pathology 3500
Jessica Shepherd
Pathology 3500 Lecture Notes - Lecture 36: Hyaline Cartilage, Synovial Fluid, Pannus
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Joints Solid BonySynostosis Boneonbone fused Ex. skull FibrousSyndesmosis Held together by fibrous tissue CartilaginousSymphysis Held together by cartilage Ex. vertebrate CavitatedSynovial Has a space (true space) and join...

Pathology
Pathology 3500
Jessica Shepherd
Pathology 3500 Lecture Notes - Lecture 35: Receptive Aphasia, Spinal Cord Injury, Hemiparesis
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Neurological Syndromes Paresis Weakness Still some strength Plegia No strength left Hemiplegia vs hemiparesis Hemiparesis Muscle weakness on half of the body Hemiplegia Spinal cord injury Paraplegia vs paraparesis Parapleg...

Pathology
Pathology 3500
Jessica Shepherd
Pathology 3500 Lecture Notes - Lecture 34: Intracranial Pressure, Subarachnoid Space, Basement Membrane
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PATH MARCH 16 Uniqueness of the CNS Functional localization Bony encasement (closed box) Increased intracranial pressure Herniations When there is increased pressure Brain will move from an area of higher pressure to an ar...

Pathology
Pathology 3500
Jessica Shepherd
Pathology 3500 Lecture Notes - Lecture 33: Spina Bifida, Intracranial Pressure, Neural Crest
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Neuropathology Lecture Objectives Gross and Microscopic anatomy Nervous system response to disease Cerebral herniation Intracranial pressure What happens to the brain if there is excess pressure Regeneration Common neurolo...

Pathology
Pathology 3500
Jessica Shepherd
Pathology 3500 Lecture 31: Burden of Cardiovascular Disease II
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PATH MARCH 7 Hypertension Systolic (120 Pressure during heart contraction Diastolic (80) Pressure during relaxation of the heart (heart filling) Longer duration Considered more important since it is longer Mean Arterial Pr...

Pathology
Pathology 3500
Jessica Shepherd
Pathology 3500 Lecture Notes - Lecture 30: Atheroma, Cerebrovascular Disease, Cardiovascular Disease
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Burden of Cardiovascular Disease Circulatory system disease aka cardiovascular disease is diseases of the heart and cerebrovascular disease (plus other) 2nd3rd leading cause of death in Canada 1st and 2nd worldwide Inciden...

Pathology
Pathology 3500
Jessica Shepherd
Pathology 3500 Lecture Notes - Lecture 28: Common Bile Duct, Common Hepatic Duct, Hepatic Veins
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Hepatobiliary DIsease Lecture Outcomes Anatomy 12001500g 2 main lobes (left and right) Dual blood supply Oxygenated blood from hepatic artery Portal vein Deoxygenated blood that passed through the GI tract How the ingested...

Pathology
Pathology 3500
Jessica Shepherd
Pathology 3500 Lecture 27: Diseases of the GI Tract II
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PATH FEB 14 Large Bowel Anatomy Ascending colon Hepatic flexure Transverse colon Splenic flexure Descending colon Sigmoid colon Rectum Diverticulum Medical term for an outpouching of a hollow (or fluid filled) structure in...

Pathology
Pathology 3500
Jessica Shepherd
Pathology 3500 Lecture 26: Diseases of the GI Tract I
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Disease of the Gi tract Lecture Outline Introduction Esophageal cancer Peptic ulcer disease Appendicitis Disease of the GI tract Colonic diverticular disease Inflammatory bowel disease Crohns disease Ulcerative colitis I t...

Pathology
Pathology 3500
Jessica Shepherd
Pathology 3500 Lecture Notes - Lecture 24: Pituitary Adenoma, Basal Metabolic Rate, Hyperfunction
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Lecture 009: Endocrine Disease II Posterior Pituitary Hyper/Hypofunction Too much ACTH release Cancer cells (adenomas) produce this hormone Cushings Syndrome Hypertension T...

Pathology
Pathology 3500
Jessica Shepherd
Pathology 3500 Lecture Notes - Lecture 23: Pancreatic Islets, Thyroid, Parathyroid Gland
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Lecture 008: Endocrine Disease I Objectives Describe the endocrine system in the broadest sense Know the difference between exocrine, endocrine, paracrine, and autocrine systems Be able to give e...

Pathology
Pathology 3500
Jessica Shepherd
Pathology 3500 Lecture 21: Molecular Genetics
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Lecture 006: Molecular Genetics The central dogma of molecular biology Flow of genetic information DNA > RNA > protein Function is mainly in protein (+ some RNA) Can also go backwards RNA > DNA Genetic information can be i...

Pathology
Pathology 3500
Jessica Shepherd

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