PATH1001 Lecture Notes - Lecture 11: C-Reactive Protein, Coronary Artery Disease, Atherosclerosis
Document Summary
Pathogenesis: soft deposits of intra-arterial fat and fibrin in the vessel walls harden with time, causes occlusion to blood flow, leading cause of coronary artery and cerebrovascular disease. Also: elevated c-reactive protein (pro-inflammatory markers), increased serum fibrinogen, insulin resistance, oxidative stress, infection, periodontal disease: excess low density lipoprotein and damps are secreted. Any vascular disorder that narrows or occludes the coronary arteries. Cad to myocardial blood supply to ischaemia to acute coronary syndromes to infarction (irreversible myocardial damage) Hypertension, smoking, diabetes, obesity, increased c reactive protein, infection. Narrowing of coronary vessels occludes myocardial blood supply. Cells temporarily deprived of blood supply and o2. Complete occlusion of coronary artery causing myocardial damage. Supply of blood to important areas is reduced: heart, brain, kidney, lungs, liver and limbs. A generic term for an inability of the heart to adequately pump blood [fluids] to the body to meet metabolic requirements. Heart incapable of maintaining co (hr x sv)
