MMED1005 Lecture Notes - Lecture 6: Skeletal Muscle, Neuropeptide Y, Lipid Bilayer
NEUROTRANSMISSION
Main points:
- Diversity of neurotransmitters and receptors
- Release mechanism for transmitter vesicles
- Postsynaptic mechanisms
o Ligand gated channels
o G-protein coupled receptors
- Presynaptic actions of neurotransmitters
find more resources at oneclass.com
find more resources at oneclass.com
Information passes from a nerve cell to other cells by chemical signals (neurotransmitters)
- When an action potential (AP) reaches the ed terial of a erve, it releases a
neurotransmitter onto the next cell (another nerve cell or a muscle or a gland cell) in
the chain
- The neurotransmitter interacts with receptors on the target cell to cause an effect
- The effect may be
o Excitatory: causes an AP in the next nerve cell – makes a muscle cell contract
– causes the gland to secrete
o Inhibitory: prevents the next nerve cell from generating an AP – makes the
muscle cell relax – prevent secretion by a gland
Neurotransmitters:
- Presynaptic terminals store neurotransmitters ready for release in vesicles
o Most terminals contain more than one neurotransmitter
o **Some are too unstable to be stored
- E.g. Acetylcholine (ACh), amines, amino acids, peptides, purines (ATP)
How are they released?
- The signal is depolarisation of the presynaptic terminal
- This occurs when the AP reaches the terminal
- Depolarisation opens voltage-activated Ca channels in the terminal,
allowing a Ca influx and rise in intracellular Ca concentration in the
terminal
- Ca triggers the fusion of the vesicle to the membrane, and release of its
contents
- After the vesicle contents have been released, the vesicle is refilled and
recycled
- Acetylcholine, noradrenaline, glutamate, ATP, etc. are released in this
way.
- The neurotransmitter diffuses across the synaptic cleft to receptors || on
the postsynaptic membrane
- The neurotransmitter binds to the receptor, and initiates events in the cell
find more resources at oneclass.com
find more resources at oneclass.com
Document Summary
Postsynaptic mechanisms: ligand gated channels, g-protein coupled receptors. Information passes from a nerve cell to other cells by chemical signals (neurotransmitters) When an action potential (ap) reaches the e(cid:374)d (cid:894)(cid:858)ter(cid:373)i(cid:374)al(cid:859)(cid:895) of a (cid:374)erve, it releases a neurotransmitter onto the next cell (another nerve cell or a muscle or a gland cell) in the chain. The neurotransmitter interacts with receptors on the target cell to cause an effect. The effect may be: excitatory: causes an ap in the next nerve cell makes a muscle cell contract. Inhibitory: prevents the next nerve cell from generating an ap makes the muscle cell relax prevent secretion by a gland. Presynaptic terminals store neurotransmitters ready for release in vesicles: most terminals contain more than one neurotransmitter, **some are too unstable to be stored. Acetylcholine (ach), amines, amino acids, peptides, purines (atp) The signal is depolarisation of the presynaptic terminal. This occurs when the ap reaches the terminal.