MMED1005 Lecture Notes - Lecture 20: Pericardial Fluid, Texas State Highway Loop 1, Inferior Vena Cava

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Cardiovascular system: heart structure and function
- Lecture 1: general anatomy of the heart
- Lecture 2: how does the heart work?
- Lecture 3: blood and blood vessels
- Lecture 4: control of blood flow and blood pressure
Learning objectives:
- Describe the anatomy of the heart
- Describe the layers of the heart wall and the coverings of the heart
- Name the heart valves and describe their location, function and mechanism of
operation
- Understand the physiological basis of heart sounds
- Describe the pathways for the flow of blood through the heart
Main points:
- There are four chambers in the heart
o two atria and two ventricles
- The ride side of the heart pumps deoxygenated blood through the lungs and the left
side pumps the oxygenated blood to the body
- There are four valves in the heart
o Tricuspid, mitral, pulmonary, and aortic
- The opening of the valves depends on the pressure gradient across the valve
- Closure of the heart valves is associated with heart sounds
- During diastole, there is ventricular relaxation and filling, during systole there is
ventricular contraction and ejection
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The cardiovascular system:
- It is a giant network of blood vessels where the movement of blood is powered by
the heart
- It is a closed system that comprises:
o Heart (pumps blood)
o Blood
o Blood vessels (moves blood)
Heart anatomy:
- Located in the thorax (chest) between the lungs, above the diaphragm
- Approximately the size of a fist
- Made of a speial type of usle alled ardia usle
- Enclosed in a double-walled sac (pericardium)
- The pointy part of the heart (bottom right in diagram) is the apex
- The top part is the base of the heart
Layers of the heart wall:
- The wall of the heart comprises three layers:
o Endocardium inner layer, directly exposed to the blood
o Myocardium the thick middle layer may of cardiac muscle
o Epicardium outer thin layer
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Endocardium:
- Endo = within
- The deepest inner layer of the heart
- Comprised of endothelial cells
- Also lines the valves and the blood vessels
Myocardium:
- Myo = muscle
- Middle layer of heart
- Thickest of all the layers
- Comprised of muscle fibres
- It is the layer that contracts and relaxes and is responsible
for pumping blood
- Trabeculae carneae: ridges that project from the inner wall
of the ventricles
Epicardium: also known as the visceral layer of the pericardium
- Epi = outer
- Outermost layer of heart
- Comprised of a thin external membrane of connective tissue
- Forms part of the pericardium and also known as the visceral
layer of the pericardium
Coverings of the heart: Pericardium
Peri = around
Fluid filled sac that surrounds the heart
Protects the heart and prevents overfilling
It is comprised of:
- Serous membrane: secretes fluid, two layers:
o Visceral pericardium: also called epicardium
(above)
Visceral = closest to the organ
The first layer of the serous membrane
Directly touches the myocardium
o Parietal pericardium:
Parietal = outer layer
The second layer of serous membrane
o Pericardial cavity:
The space between the two layers
Filled with pericardial fluid, which acts as a
lubricant, allowing heart movement
- Fibrous pericardium:
o Fibrous outer layer
o Comprised of tough, dense connective tissue
o Anchors the heart in place and gives the parietal pericardium something to
adhere to
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Document Summary

Lecture 4: control of blood flow and blood pressure. Describe the layers of the heart wall and the coverings of the heart. Name the heart valves and describe their location, function and mechanism of operation. Understand the physiological basis of heart sounds. Describe the pathways for the flow of blood through the heart. There are four chambers in the heart: two atria and two ventricles. The ride side of the heart pumps deoxygenated blood through the lungs and the left side pumps the oxygenated blood to the body. There are four valves in the heart: tricuspid, mitral, pulmonary, and aortic. The opening of the valves depends on the pressure gradient across the valve. Closure of the heart valves is associated with heart sounds. During diastole, there is ventricular relaxation and filling, during systole there is ventricular contraction and ejection. It is a giant network of blood vessels where the movement of blood is powered by the heart.

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