BM1022 Lecture Notes - Lecture 19: Upper Respiratory Tract Infection, Corynebacterium Diphtheriae, Otitis Media
Document Summary
Primary viral often infection predisposes secondary bacterial infection. Upper respiratory tract colonised with a diversity of normal flora. 50% of urt flora are potentially pathogenic for lower respiratory tract or. 50% of urt flora are potentially pathogenic for lower respiratory tract or other site. Via bloodstream from another primary site of infection. Humans are the most important reservoir for bacterial infection. Tonsil / ln - sites of adaptive immune response. Cardiac and other chest surgery - prevent cough reflex. Be aware that pathogenicity is a combination of microbe, host environment. Endotoxins (if gram negative) - inducton of pro-inflammatory cytokines: pseudomallel (melioidosis) and m. tuberculosis (tb): Infection of the respiratory tract: establishment of infection: Rsv is highly contagious and causes sharp outbreaks of respiratory disease particularly in infants. particularly in infants. However, within 24 hours the baby may be severely ill with cyanosis and distress. There is a bronchiolitis with or without a pneumonitis.
