BM1022 Lecture Notes - Lecture 20: Low Birth Weight, Diarrhea, Abdominal Pain
Document Summary
Faecal oral transmission - human / animal reservoir. Affects individuals in communities that are not adequately separated from faeces. Socio-economic conditions must improve so to provide sustainable solutions. Short term solutions good for developing country researchers / pharmaceutical companies. Antimicrobial treatment can exacerbate disease and worsen prognosis. 19% of total deaths of children under five. Will continue to be a problem while poverty is endemic. Microorganism must survive harsh environment of the git. Pharmacologic action of bacteria toxins - local or distant to infection site. Local inflammation in response to superficial microbial invasion. Fluid loss - no blood, mucus, or pus in stool. Viral and toxin producing bacteria - coccidial protozoa. Diarrhoea in children under 2 years of age. In the usa over 1 million cases with 150 deaths. Mostly self limiting: typhi = typhoid, systemic disease. Gram negative bacilli, nlf, urease neg, h2s negative. If inpatient >3 days presents with acute diarrhoea.
