BCMB20002 Lecture Notes - Lecture 6: Metabolic Water, Acetyl-Coa, Transferase

• School: University of Melbourne
• Department: Biochemistry and Molecular Biology
• Course: BCMB20002
• Professor: Terry Mulhern

Document Summary

* nadph production pentose phosphate and malic enzyme. * glucose-6-phosphate is oxidised into ribose-5-phosphate, and carbon dioxide is released: nonoxidative phase: * takes ribose-5-phosphate and builds it back into glucose-6-phosphate. * the ribose-5-phosphate can be removed after the oxidate phase and be used for the backbone of nucleic acids. * supplies nadph for fat synthesis, steroid synthesis, antioxidant regeneration (glutathione) and drug detoxification. * allows 5-carbon dietary sugars to enter glycolysis as glucose-6-phosphate (non oxidative phase) * glucose-6-phosphate can be released as glucose, it can be stored as glycogen, it can be sent through glycolysis or it can be sent through the pentose phosphate pathway. * glucose-6-phosphate dehydrogenase is a regulated enzyme it removes two hydrogens from glucose-6-phosphate to form 6-phosphoglucono- -lactone. This is a cyclic organic acid that is highly unstable and it will spontaneously hydrolyse within a few minutes. * note: any 3,4,5,6,7 carbon sugar can turn into any other sugar.