BCMB20002 Lecture Notes - Lecture 5: Glyoxylic Acid, Atp Synthase, Brown Adipose Tissue
17 Aug 2018
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* the krebs cycle will stop if there is a shortage of nad+ The krebs cycle is not only a way of burning carbon dioxide out of acetyl-coa, it is a way of getting other substrates (and other intermediates). * the krebs cycle can be depleted by taking out citrate which can be used to make fatty acids & sterols. But, the krebs cycle never stops because oxaloacetate can be made in a number of ways. * the krebs cycle is only turned on when we need energy. * the first step into committing to the krebs cycle is turning on pyruvate dehydrogenase (phosphatase turns it on). It is turned on when there is low energy and it is turned off by high energy and acetyl-coa. * acetyl-coa is the breakdown product of fatty acids. When starving: use fatty acids, not pyruvate to generate acetyl-coa. *the krebs cycle can be turned off by nadh and high.
