BIOL10003 Lecture Notes - Lecture 19: Sickle-Cell Disease, Hemoglobin A, Hbb

• School: University of Melbourne
• Department: Biology
• Course: BIOL10003
• Professor: All

Document Summary

Lecture 19 multiple alleles and other extensions to mendel. Most common allele in the total population. Homologous chromosomes have the same genes but may have different alleles. Allele segregation; halving chromosome number before fertilisation. When drawing punnet squares, include genotypic and phenotypic ratio e. g. 1/4 bb:1/2 bb:1/4 bb. Co-dominance blended but both alleles visible independently. Multiple alleles each gene locus can have many alleles. Pleiotropy a single gene may affect many features of the phenotype i. e. has a cascade of events. Phenocopy a phenotypic copy one is inherited, one due to the environment e. g. a mother taking thalidomide can give the baby meromelia, which is the same as inherited meromelia also occurs with rickets. Hba hbs unstable (normal and sickled cells)