BIOL10004 Lecture Notes - Lecture 20: Seminiferous Tubule, Leydig Cell, Sertoli Cell

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BIOL - Lecture 20
Reproduction II
Testis
Structure and function
sperm production
o occurs in seminiferous tubules
o controlled by Sertoli (nurse) cells
o spermatogenesis
hormone production
o testosterone steroid, androgen
o made by Leydig cells in between
tubules
spermatogenesis
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hormones: testosterone
produced by Leydig cells
acts via androgen receptors in cells
can be converted to oestradiol by Sertoli cells to aid spermatogenesis or to DHT
stimulates accessory sex organs prostate, seminal vesicles etc.
modulates secondary sex characteristics and male-type behaviour courtship,
aggression etc.
production body hair, voice breaks, muscle growth
control of Testis function
hypothalamo-pituitary-gonadal (HPG) axis
gonadotrophin releasing hormone (GnRH)
from hypothalamus stimulates release of LH
and FSH (gonadotrophins) from pituitary
o LH stimulates Testosterone (T)
production by testis
o FSH stimulates spermatogenesis by
working on Sertoli cells
T positively affects accessory sex organs
T inhibits GnRH and LH secretion, while
Inhibin (from Sertoli cells) inhibits FSDH
secretion negative feedback
Relatively constant T homeostatic control
Ovaries
Structures
Ovoid shape
Surface tough epithelium
Cortex germ cells, follicles, corpora lutea (CL), corpora albicans
Medulla fibrous connective tissue, blood vessels, nerves
Development of these structures is a continuous process
o Always follicles at each stage (but fixed number set at birth)
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