BIOM20001 Lecture Notes - Lecture 27: Rett Syndrome, Mecp2, X-Inactivation

32 views5 pages
29 Sep 2018
Department
Course
Professor

Document Summary

Histones with varying stabilities or specialist domains that alter the function of the nucleosome. Enzymes can move or remove the nucleosomes to alter accessibility by the transcriptional machinery. Chromosome structure centromeres and telomeres (constitutive heterochromatin, h3k9me and often dna methylation) Tissue and developmental time-point specific patterns of gene expression (facultative heterochromatin, h3k27me and rarely dna methylation) X-inactivation is an epigenetic dosage compensation mechanism in mammals, so that males and females have the same dose of genes on the x chromosome. Random x-inactivation occurs at gastrulation in the embryo, then this epigenetic state is mitotically inherited by each daughter cell e. g. visual appearance in calico cats. Ginger gene for ginger colour (g), null allele of this gene black coat (g). Coat colour patches and x inactivation maintained for the lifetime of the female mammal, due to mitotic heritability of epigenetic marks on the inactive x. Calico or tabby tom cats are very rare, and are xxy.

Get access

Grade+
$40 USD/m
Billed monthly
Grade+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
10 Verified Answers
Class+
$30 USD/m
Billed monthly
Class+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
7 Verified Answers

Related Documents