NEUR30003 Lecture Notes - Lecture 20: Nmda Receptor, Ketamine, Low Frequency

• School: University of Melbourne
• Department: Neuroscience
• Course: NEUR30003
• Professor: Peter

Document Summary

Lecture 8. 3 learning and memory - mechanisms. Synapses strengthen when the presynaptic terminals and post-synaptic neurons are active at the same time. Long term depression (ltd) a hebbian modification. Synapses weaken when pre- and post-synaptic activity is not simultaneous. Blue dots are responses to stimuli applied to one part of the input to a hippocampal ca1 neuron (pyramidal cell) Arrow = point of tetanus: tetanic stimulation = very high frequency stimulation. Response to activation of the originally stimulated axons, no change. Stimulated -> last much longer for at least a month. Stimulate one group of axons at low frequency in conditioning stimulus phase. No change in responses to stimulating other axons. Low frequency stimulation doesn"t activate post-synaptic neuron -> the ones that were stimulated produce a much smaller response: persists for long period of time. Both are enough to produce a memory. Sleep allows for relative changes in synaptic strength rather than absolute changes.