PHYS20009 Lecture Notes - Lecture 10: Endoplasmic Reticulum, Neuromuscular Junction, Tetanus
7 Sep 2018
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Ec coupling: somatic motor neuron releases acetylcholine at neuromuscular junction, net entry of na+ through acetylcholine receptor-channel on muscle side of neuromuscular junction initiates a muscle action potential. * at low frequency there will be a single muscle twitch. * if two stimuli are close to each other, then the twitches will summate. * if there is a large amount of stimulation at a large frequency, tetanus will occur. * tetanus is the maximum number of calcium (maximum amount of calcium is still being released at twitch too) binding to filaments and the maximum sliding of filaments. * to deliver oxygen (via the blood) to working muscles via local vasodilation. * restrict blood flow to other areas (viscera, non-working skeletal muscles etc. ) via local vasoconstriction. * vasodilation will be overriding in dynamic exercise. * during dynamic exercise, tpr will decrease which is indicative of vasodilation. * dynamic exercise recruits many muscle groups, thus requires more wide-spread oxygen delivery.
