PHYS30005 Lecture Notes - Lecture 4: Diabetes Mellitus Type 2, High Intensity Training, Protein Kinase
13 Aug 2020
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Energy status: changes as the muscle breaks down atp and other fuels. Redox (changes in state because of reactions that occur) ** changes in expression and/or activity of key proteins affects size and functional properties of skeletal muscle. Resistance type exercise -------> endurance/high intensity (adaptations more related to muscle mass/hypertrophy) Muscle adaptations to endurance exercise focus on increasing oxidative capacity of the muscle. Reduced reliance on carbohydrate reduced lactate production increased fat oxidation during exercise. Improved insulin action (important in minimizing risk of metabolic diseases eg. type. Example study: endurance impact on glut4 transport protein. Oxidative capacity measured by max enzyme activity in mitochondria of citrate synthase. Higher oxidative capacity and higher glut4 in trained athletes. Trained subjects stopped regular training for 10 days -> reduction in oxidative capacity and glut4 expression: ** cessation of training diminished these adaptive responses (didn"t fall all the way down to untrained level)
