PSYC30020 Lecture Notes - Lecture 13: Extracellular Fluid, Astrocyte, Ad Libitum
Lecture 13
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- Total sleep deprivation in rats
- Rechtschaffen Sleep 1989
- Rats died or were sacrificed when near death after 10-20 days of total sleep
deprivation
- Causes were mixed: Infections, organ failure, hypothermia (although warming them
didn’t alter mortality)
- Rats deprived of food (ad lib water) live ~30 days
- Rats deprived of REM only died after 45 days
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- Energy Conservation Theory:
- Weak Form → immobility is associated with lower levels of energy expenditure than
activity. Thus immobility itself conserves energy
- Strong Form → sleep actively lowers energy expenditure below that of immobile
wakefulness
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- Collet et al. Sleep 2016: 12 healthy men, sleep studies for one week done at
- ⇒ Baseline with caloric intake fixed at required level
- ⇒ After 2 days caloric restriction to 10% of requirements
- ⇒ After 2 days of ad lib food recovery
- Criticism of Energy Conservation Theory:
- → Fall in metabolic rate during sleep is small in magnitude
- → Active heat loss associated with sleep onset, lose heat in hands and feet, easier to
sleep after warm bath
- → Negative correlation over species between (relative) basal metabolic rate and
sleep duration in mammals, but no relationship in birds
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Document Summary
Rats died or were sacrificed when near death after 10-20 days of total sleep deprivation. Causes were mixed: infections, organ failure, hypothermia (although warming them didn"t alter mortality) Rats deprived of food (ad lib water) live ~30 days. Rats deprived of rem only died after 45 days. Weak form immobility is associated with lower levels of energy expenditure than activity. Strong form sleep actively lowers energy expenditure below that of immobile wakefulness. Sleep 2016: 12 healthy men, sleep studies for one week done at. Baseline with caloric intake fixed at required level. After 2 days caloric restriction to 10% of requirements. After 2 days of ad lib food recovery. Fall in metabolic rate during sleep is small in magnitude. Active heat loss associated with sleep onset, lose heat in hands and feet, easier to sleep after warm bath. Negative correlation over species between (relative) basal metabolic rate and sleep duration in mammals, but no relationship in birds.