VETS20015 Lecture Notes - Lecture 8: Genetic Disorder, Quantitative Genetics, Mutation Rate
5 Aug 2018
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Document Summary
Disorders run in families (familial: because the incident rate in general is greater than general. Tens of thousands of genes: expect tens of thousands of potential genetic disorders: small proportion already identified- but still thousands. Still thousands of potential single gene disorder: simple mendelian inheritance may apply. Unlikely to be genetic if sudden increase in prevalence of a disorder in a population to moderate levels (say 10%: unless sudden and intense increase in inbreeding- check. Four types of inheritance/four types of disease distribution: autosomal recessive, by far the most common, it is difficult to reduce recessive allele frequency, autosomal dominant, x-linked recessive, x- linked dominant. Autosomal recessive by far most common, even assuming common mutation rate: difficult to reduce recessive gene frequency to very low levels in populations. Will express itself as follows: may skip generations, all offspring of 2 affected parents are affected, approx equal numbers of males and females.
