MEDI7212 Lecture Notes - Lecture 99: Psychomotor Retardation, Esophageal Candidiasis, Histology
Document Summary
Leukaemia (malignant cells replace functional immune cells: malnutrition, burns, chemotherapy (toxic to bone marrow cells, certain infections (hiv, deliberate immunosuppression of transplant recipients or allergy/ autoimmune/ inflammatory condition. Initial viremic phase - self-limited, febrile viral syndrome characterised by fatigue, pharyngitis, myalgia, maculopapular rash, lymphadenopathy and significant viremia without detectable anti- Hiv antibodies: asymptomatic stage - seroconversion and clinical latency period; massive viral replication in lymph tissues with no detectable virus in peripheral blood. Symptomatic stage - progressive decline in cd4 t cells, reversal of. Pathogenesis hiv (group of retroviruses: virion entry and cellular infection via gp120 (hiv) binding to cd4 surface receptor molecules, also binding to macrophages via ccr5- Important clinical indicator of immune status in hiv-infected individuals: direct correlation between cd4 count and risk of aids-defining opportunistic infections and malignancy. Clinical presentation: cd4 count for disease staging & viral load for disease progression or monitoring response to therapy.
