IMED3001 Lecture Notes - Lecture 9: Acute Kidney Injury, Volumetric Flow Rate, Creatinine
28 May 2020
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L9: renal & acid-base disorders: not validated for children or pregnancy acute kidney injury. Removes waste products and toxins including urea, creatinine, urate, so4, po4, nh3, drugs. Regulatory: maintains blood volume, osmolality, electrolytes, ph. Amount of blood filtering through the kidney per minute: normal = 90-150 ml/min. Determined by the clearance of a substance which is freely filtered and not reabsorbed or secreted, metabolised or excreted elsewhere. Clearance = urine concentration x urine volume flow rate / plasma concentration. Difficult to find something that is only excreted via free filter in the kidney. Simplest way to estimate gfr is via blood test ~ creatinine. Creatinine is a breakdown product of creatine phosphate in muscle. But not reliable for early chronic kidney disease acute kidney injury extreme body size elderly increase in creatinine compared to a previous result is best marker of early renal disease. Cockcroft and gault creatinine female= x 1. 04 for drug dosing.
