BIOL122 Lecture Notes - Lecture 1: Membrane Transport Protein, Integral Membrane Protein, Pharmacology
Document Summary
1. 0 definition of pharmacokinetics: this is a branch of pharmacology concerned with the movement of drugs within the body. Ie it studies what the body does to the drug and how it moves within the body. It is considered less effective that the bbb: blood-brain (barrier), the blood brain barrier prevents the brains uptake of most drugs, certain small molecule drugs may cross the bb via lipid diffusion. It occurs most within the liver due the fact the liver has the highest concentration of biotransformation enzymes: hepatic first-pass effect, this is often known as the first pass metabolism. It is a form of drug metabolism whereby a concentration of drug is reduced before it reaches systematic circulation: this pass through the liver greatly reduces the bioavailability of the drug. 1. 6 drug excretion: routes of excretion, excretion is the process by which the drugs are passes to the external environment. Renal excretion: this is the process that occurs within the kidney.