BMSC207 Lecture Notes - Lecture 10: Coccidioidomycosis, Human Microbiota, Tinea Cruris
Fungal Pathogens and discovery of antibiotics:
Eukaryotic pathogens:
-->•
Fungal infections:
Now increasingly common○
Once exotic and rare•
Opportunistic•
Fungi are non 'virulent' •
Adhesions for attachment •
Secrete enzymes to modify environment•
Toxins•
Create allergic responses •
Fungal biology:
•
Eukatyotic•
Non-motile•
Aerobic•
Saprophytic or parasitic•
Cell wall contains glycan and chitin•
Cell membrane contains ergosterol•
Fungi can be gram stained•
Fungal infections:
○
Infection classification scheme:•
Pathogenesis:
Produced but not relevant to human infections
○
Toxins:•
Bulk organisms○
Immune response is to them or their by-products○
Or if severely immunocompromised○
Disease from:•
Fungal infections:
Superficial (skin or mucosa)•
Subcutaneous•
Infect healthy hosts , disease worsens if immunocompromised
True pathogens:
○
Disease almost exclusively in immunocompromised individuals
Opportuni sts:○
Systemic:•
Superficial infections:
Mould producing keratinase (enzyme that breaks down keratin)
Dermatophytes:•
Lecture 5.1 - 29/8/16
Monday, 29 August 2016
10:40 AM
Lectures Page 1
