BMS130 Lecture Notes - Lecture 2: Hematocrit, Spectrin, Hemoglobin

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28 Jun 2018
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CARDIOVASCULAR SYSTEM
Lecture 1 - Erythrocytes and Hemoglobin
Describe the structure and function of erythrocytes and their relationship
to hemoglobin
Erythrocytes
Structure
Function/Relationship
Disc-shaped cell of 7.5 μm diameter
and 2.0 μm thick at rim
Gas transport of O2 to tissues and
CO2 to lungs
Increased surface area/volume ratio of
an RBC increases diffusion rate of
these gases
Lacks organelles like mitochondria
Majority of O2 (98.5%) in the blood is
transported within the RBC attached to
the hemoglobin (Hb) molecules
Anucleate
Contains cytoskeleton proteins
(spectrin & actin) that give membrane
resilience
RBCs contain hemoglobin (red
pigment molecule), they are little more
than ‘bags’ of hemoglobin
Hemoglobin (Hb)
- Hb is an iron/protein pigment molecule found in the blood
- Heme groups
- Conjugate with each protein chain
- Hemoglobin molecule can carry four O2
- Binds an O2 to iron component at its centre
- Globins - 4 protein chains
- 2 alpha and 2 beta chains each around 140 amino acids long
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Document Summary

Describe the structure and function of erythrocytes and their relationship to hemoglobin. Disc-shaped cell of 7. 5 m diameter and 2. 0 m thick at rim. Increased surface area/volume ratio of an rbc increases diffusion rate of these gases. Majority of o2 (98. 5%) in the blood is transported within the rbc attached to the hemoglobin (hb) molecules. Contains cytoskeleton proteins (spectrin & actin) that give membrane resilience. Rbcs contain hemoglobin (red pigment molecule), they are little more than bags" of hemoglobin. Hb is an iron/protein pigment molecule found in the blood. Binds an o2 to iron component at its centre. 2 alpha and 2 beta chains each around 140 amino acids long. State the normative values for hematocrit, hemoglobin concentration and red blood cell count and state reasons for differences between men and women. Hematocrit: % of whole blood volume composed of rbcs. Rbc count and hemoglobin concentration indicate amount of o2 blood can. Testosterone stimulates rbc production, less in women.

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