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Class Notes for BCCB2000 at Curtin University

Foundations of Biochemistry

BCCB2000 Lecture Notes - Lecture 19: Arsenic, Lipoic Acid, Pantothenic Acid

Tricarboxylic Acid (TCA) Cycle AKA Krebs Cycle or Citric Acid Cycle Dr Steven Bottomley TCA Cycle: Otherwise known as Krebs cycle or citric acid cycle Final common pathway for oxidation of fuel molecules o Amino acids, f...

Biochemistry
BCCB2000
Dr Steven Bottomley
BCCB2000 Lecture Notes - Lecture 18: Primaquine, Hexose, Glyceraldehyde

Pentose Phosphate Pathway and NADPH Dr Steven Bottomley PPP and Glucose Metabolism: Where is the Pentose Phosphate Pathway: Reaction occur in cytosol of cells Major tissues where PPP is active includes: o Adipose tissue ...

Biochemistry
BCCB2000
Dr Steven Bottomley
BCCB2000 Lecture Notes - Lecture 12: Non-Coding Rna, Purine, Small Nuclear Rna

Nucleotides and Nucleic Acids Dr Steven Bottomley Importance of Nucleotides o Precursors of nucleic acids DNA and RNA o Precursors of energy carriers ATP and GTP o Components of ...

Biochemistry
BCCB2000
Dr Steven Bottomley
BCCB2000 Lecture Notes - Lecture 16: Phosphoglucomutase, Glucokinase Regulatory Protein, Glucokinase

Glycolysis and Glycogenolysis: Dr Steven Bottomley Glucose Metabolism: - Major fuel of most organisms with a free energy of oxidation -2864 kJ/mol - Also supplies large array of ...

Biochemistry
BCCB2000
Dr Steven Bottomley
BCCB2000 Lecture Notes - Lecture 17: Triose, Alanine, Cori Cycle

Gluconeogenesis Dr Steven Bottomley Energy Stores in the Human Body: Gluconeogenesis: Gluco glucose; neo new; genesis formation Synthesis of glucose from noncarbohydrate precursors Source of glucose o Maintain blood glu...

Biochemistry
BCCB2000
Dr Steven Bottomley
BCCB2000 Lecture Notes - Lecture 23: Blood Sugar, Renal Cortex, Transferase

Fed, Fasting, Starvation, and Diabetes Dr Steven Bottomley Pathways: Pathway Substrates Products Anabolic Gluconeogenesis Lactate, Alanine, Glycerol Glucose Glycogen Synthesis Glucose1phosphate Glycogen Lipogenesis Acetyl ...

Biochemistry
BCCB2000
Dr Steven Bottomley
BCCB2000 Lecture Notes - Lecture 21: Liver Disease, Electron Transport Chain, Malabsorption

Fatty Acid Metabolism Dr Steven Bottomley Why are Fats Good Stores of Energy? - The long chain alkyl hydrocarbon chains of fatty acids have an energy of oxidation more than ...

Biochemistry
BCCB2000
Dr Steven Bottomley
BCCB2000 Lecture Notes - Lecture 20: Intermembrane Space, Enzyme, Dinitrophenol

Electron Transport and Oxidative Phosphorylation Dr Steven Bottomley Niacin and NAD : {+ - NAD /NADH needs nicotinamide o A derivative of niacin - Niacin (nicotinic acid) can...

Biochemistry
BCCB2000
Dr Steven Bottomley
BCCB2000 Lecture 15: Concepts of Metabolism

Concepts of Metabolism Dr Steven Bottomley Why Study Metabolism? Allows us to see how life works Defects in metabolism lead to disease and pathology Metabolism determines what is happening in a cell at a particular time...

Biochemistry
BCCB2000
Dr Steven Bottomley
BCCB2000 Lecture Notes - Lecture 14: Electronegativity, Hepatocyte, Heme

Bioenergetics 2: Dr Steven Bottomley Review Gibbs Free Energy (G): - Negative Free Energy (-G) means the reaction is spontaneous o Exergonic - Positive Free Energy (+G)...

Biochemistry
BCCB2000
Dr Steven Bottomley
BCCB2000 Lecture Notes - Lecture 13: Exothermic Reaction, Endothermic Process, Kinetic Energy

Bioenergetics 1: Dr Steven Bottomley Characteristics of Life: Complicated structure and highly organised Ability to extract, manage, and use matter Ability to extract, transform, manage, and use energy Ability to synth...

Biochemistry
BCCB2000
Dr Steven Bottomley
BCCB2000 Lecture 22: Amino Acid Catabolism and the Urea Cycle

Amino Acid Catabolism and the Urea Cycle Dr Steven Bottomley Amino Acid Metabolism: Amino acids are a source of energy they contribute about 1015 of metabolic energy (although in some carnivores they provide up to 90 of e...

Biochemistry
BCCB2000
Dr Steven Bottomley

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