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Class Notes for PATH1001 at Curtin University

Foundations of Pathophysiology

PATH1001 Lecture Notes - Lecture 1: Diabetic Nephropathy, Hypertension, Gestational Diabetes

Basic concepts of Pathophysiology Diabetes Diabetes is a metabolic disease of the pancreas that is located behind the stomach. The pancreas produces insulin, which is delivered into every cell in the body Symptoms include:...

Pathology
PATH1001
Kate Smith
PATH1001 Lecture Notes - Lecture 2: Wound Healing, Hyperlipidemia, Frostbite

Textbook Altered Cellular Function (chap 4) Causes of Cellular Injury Most disease begin with cell injury Cellular injury occurs if cell cant maintain homeostasis when faced with injurious stimuli ie lack of 02 (hypoxia), ...

Pathology
PATH1001
Kate Smith
PATH1001 Lecture Notes - Lecture 2: Neurapraxia, Spasm, Tendinopathy

Cell Injury and Inflammation A key tenet of pathology is that all disease is a manifestation of cell injury of some sort Cell Injury Reversible (non-lethal=cells can go back to normal) Hypoxia-transient ischaemic a...

Pathology
PATH1001
Kate Smith
PATH1001 Lecture Notes - Lecture 3: Hematoma, Bone Healing, Hemostasis

Tissue Healing and Repair No injury can be made to heal faster than its natural speed; all that can be done is to ensure that all favorable conditions are encouraged Inflammation is said to be resolved when: No more struct...

Pathology
PATH1001
Kate Smith
PATH1001 Lecture Notes - Lecture 4: Hyaline Cartilage, Synovial Joint, Synovial Fluid

Joint Disease Synovial Joints (most commonly affected my artritis) Synovial Membrane There are 2 types of synoviocytes: -A=Phagocytic to maintain synovial fluid integrity (macrophage like) -B=secr...

Pathology
PATH1001
Kate Smith
PATH1001 Lecture 6: Autonomic Nervous System

Autonomic Nervous System Autonomic Unconsciously perceived visceral sensations involuntary inhibition or excitation of smooth muscle, cardiac muscle or glandular secretion Two neurons needed to connect CNS to organ (as par...

Pathology
PATH1001
Kate Smith
PATH1001 Lecture Notes - Lecture 7: Pulmonary Pleurae, Pleural Cavity, Intrapleural Pressure

Topic 7 Acute and Chronic Pulmonary Disease Anatomy Pleura Pleural sac encases each lung Parietal pleura Pleural cavity Closed potential space Small amount of pleural fluid lubricates Intrapleural pressure is lower than...

Pathology
PATH1001
Kate Smith
PATH1001 Lecture Notes - Lecture 8: Bronchiole, Pulmonary Heart Disease, Acinus

Acute and Chronic Pulmonary Disease Emphysema (pathological def) The permanent enlargement of airspaces distal to terminal bronchioles & destruction of alveolar walls. -Caused by: Smoking, a1-antitrypsin deficiency -Le...

Pathology
PATH1001
Kate Smith
PATH1001 Lecture Notes - Lecture 10: Coronary Artery Disease, Coronary Circulation, Thoracic Vertebrae

Cardiovascular Disease 1 Case Study: cardiovascular Condition 48 yr old male Successful barrister, father of three Lifelong endurance athlete (7 ironman, English channel swim, marathons) Medical hist...

Pathology
PATH1001
Kate Smith
PATH1001 Lecture Notes - Lecture 11: C-Reactive Protein, Coronary Artery Disease, Atherosclerosis

Cardiovascular Disease Pathogenesis Soft deposits of intraarterial fat and fibrin in the vessel walls harden with time Causes occlusion to blood flow Leading cause of coronary artery and cerebrovascular disease Stages: Inj...

Pathology
PATH1001
Kate Smith
PATH1001 Lecture Notes - Lecture 12: Blood Sugar, Insulin, Metabolic Disorder

Insulin and Diabetes Diabetes Mellitus Metabolic disorder: Abnormal chemical reactions that alter the normal metabolic processes Characterised by Abnormal secretion andor action of insulin Hyperglycaemia (high blood glucos...

Pathology
PATH1001
Kate Smith
PATH1001 Lecture 13: Renal Pathophysiology

Renal Pathophysiology Kidney Function Excretion Regulation of blood volume and pressure Regulation of blood solute concentration Regulation of pH levels of the extracellular fluid Regulation of red blood cell synthesis Rem...

Pathology
PATH1001
Kate Smith

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