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Class Notes (1,030,921)
AUS (35,044)
UniMelb (5,189)
BCMB (128)
BCMB30004 (24)

Class Notes for BCMB30004 at University of Melbourne

Cell Signalling and Neurochemistry

BCMB30004 Lecture Notes - Lecture 37: Platelet-Derived Growth Factor, Insulin Receptor, Steric Effects
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Pre-recorded lecture PROTEIN KINASE INHIBITORS AS ANTI-CANCER THERAPUTICS: * Gleevac (also called Imantinib, Glivec and STI-571) as therapeutics for the treatment of chronic myelogenous leukaemia. * There are 518 pr...

Biochemistry and Molecular Biology
BCMB30004
Professor Cheng
BCMB30004 Lecture Notes - Lecture 36: Missense Mutation, Gene Duplication, Amphiphile
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Lecture 36 PHYSIOLOGICAL FUCNTIONS & BIOCHEMICAL PROTERTIES OF -SYNUCLEIN: Familial PD-causative mutations of -synuclein gene: * -synuclein is autosomal dominant. * There are two types of mutations: the missense mutat...

Biochemistry and Molecular Biology
BCMB30004
Professor Cheng
BCMB30004 Lecture Notes - Lecture 35: L-Dopa, Synuclein, Mptp
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Lecture 35 MOLECULAR BASIS OF PATHOGENESIS OF PARKINSONS DISEASE: The three dopaminergic neuronal pathways: * Parkinsons disease is due to premature death of a region of brain cells in a region of the brain called the...

Biochemistry and Molecular Biology
BCMB30004
Professor Cheng
BCMB30004 Lecture Notes - Lecture 34: Cytoskeleton, Neuroprotection, Fkbp
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Lecture 34 PHOSPHORYLATION-DEPENDENT PROLYL CIS TRANS ISOMERISATION AND ALZHEIMER'S DISEASE: PART 1: PROLYL CIS/TRANS ISOMERISATION AS A REVERSIBLE POST-TRANSLATIONAL MODIFICATION IN CELL SIGNAL TRANSDUCTION: * ...

Biochemistry and Molecular Biology
BCMB30004
Professor Cheng
BCMB30004 Lecture Notes - Lecture 27: Hydroxycarbamide, Methyl Group, Chromosomal Translocation
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Lecture 27 TYROSINE KINASE INHIBITOR THERAPY IN THE MANAGEMENT OF CHRONIC MYELOID LEUKAEMIA: Patient details: * Female, 50 years * Presented in May 2005 with body aches, tiredness and was feeling Not quite right * No other...

Biochemistry and Molecular Biology
BCMB30004
Professor Cheng
BCMB30004 Lecture Notes - Lecture 20: Intermembrane Space, Tradd, Deubiquitinating Enzyme
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Lecture 20 CELL DEATH: Mechanisms of cell death: * Necrosis * Apoptosis * Necroptosis * Autophagy NECROSIS: * Necrosis occurs when you injure a cell so it is death by injury and this injury can be mechanical, chemical or h...

Biochemistry and Molecular Biology
BCMB30004
Professor Cheng
BCMB30004 Lecture Notes - Lecture 19: Phosphatidylinositol, Permease, Cell Membrane
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Lecture 19 NUCLEATION COMPLEX: * This involves a complex and it is a class 3 PI3K (VPS34: phosphatidylinositol 3phosphate) and this adds a phosphate to C3 of the inositol ring. Note: in the induction complex there is a cla...

Biochemistry and Molecular Biology
BCMB30004
Professor Cheng
BCMB30004 Lecture Notes - Lecture 18: Cytosol, Proline, Stk11
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Lecture 18 AUTOPHAGY: * Autophagy is a pathway where cells recycle their contents and this pathway is often used under starvation conditions. Autophagy: * Autophagy is a pathway where cells degrade and recycle contents. * ...

Biochemistry and Molecular Biology
BCMB30004
Professor Cheng
BCMB30004 Lecture Notes - Lecture 16: Presenilin, Epsin, Amyloid Precursor Protein Secretase
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Lecture 16 & 17 UBIQUITIN: * Ubiquitin is a tag that modifies proteins. * Ubiquitin is a small protein: 76 amino acids, 8.5 kDa. * Ubiquitin attaches to proteins via a covalent bon...

Biochemistry and Molecular Biology
BCMB30004
Professor Cheng
BCMB30004 Lecture Notes - Lecture 15: Decoy, Tryptophan, Cyclic Adenosine Monophosphate
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Lecture 15 PROTEIN KINASE STRUCTURES AND REGULATION PART 2: The different isoforms of PKA regulatory and catalytic subunits: * There are type 1 type 2 regulatory subunits and even these have alpha and beta which are encod...

Biochemistry and Molecular Biology
BCMB30004
Professor Cheng
BCMB30004 Lecture Notes - Lecture 14: Consensus Sequence, Intrinsically Disordered Proteins, Alanine
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Lecture 14 PKI: * PKI is a naturally occurring protein inhibitor of cAMP-dependent protein kinase (PKA) * PKI is a specific inhibitor of PKA and it inhibits PKA by binding to the substrate-binding site. * PKI is a very ...

Biochemistry and Molecular Biology
BCMB30004
Professor Cheng
BCMB30004 Lecture Notes - Lecture 13: Lone Pair, Phosphorylase, Ribose
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Lecture 13 ENZYMES CATALYZING PROTEIN PHOSPHORYLATION DEPHOSPHORYLATION PROTEIN KINASE STRCTURES AND FUNCTIONS 1: * Human kinome: kinases expressed in the human genome. There are ~ 500 kinases in humans and 16 are protein...

Biochemistry and Molecular Biology
BCMB30004
Professor Cheng
BCMB30004 Lecture Notes - Lecture 12: Mammalian Genome, Ube2I, Prostate Cancer
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Lecture 12 SUMO WEIGHS IN: Ubiquitin Ubiquitination: * Ubiquitin: peptide (76 amino acids (this is a small sequence so it is called a peptide instead of a protein), approximately 8.5 kD mass and when these molecules are a...

Biochemistry and Molecular Biology
BCMB30004
Professor Cheng
BCMB30004 Lecture Notes - Lecture 11: Tubulin, Microtubule, Futile Cycle
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Lecture 11 OGLCNAC ITS CROSSTALK WITH PHOSPHORYLATION: * OGlcNAc is a carbohydrate or a form of sugar. * At least a 1000 different proteins that we recognise are modified by this sugar molecule (O GlcNAc). * Almost all pr...

Biochemistry and Molecular Biology
BCMB30004
Professor Cheng
BCMB30004 Lecture Notes - Lecture 10: Hydroxylation, Grb2, Ube2I
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Lecture 10 Introduction to posttranslation modification diversity and function: CENTRAL DOGMA OF GENE EXPRESSION: * The central dogma diagram below represents how information flows from DNA which stores the information thr...

Biochemistry and Molecular Biology
BCMB30004
Professor Cheng
Permachart - Marketing Reference Guide: Extensor Carpi Ulnaris Muscle, Flexor Pollicis Longus Muscle, Abductor Digiti Minimi Muscle Of Hand

perm ach artsMT T rigger Points II: Extremities T rigger Points II: Extremities ...

ANAT - Anatomy
ANAT 14
All Professors
ANAT - Anatomy
ANAT 14
All Professors
ANAT - Anatomy
ANAT 14
All Professors
Permachart - Marketing Reference Guide: Sacral Plexus, Lumbar Plexus, Sympathetic Ganglion

pe rm a ch ar ts MT Spinal Cord 2nd EDITION Figure ...

ANAT - Anatomy
ANAT 14
All Professors
Multicellular Biology - Reference Guides

This Guide is the progressive companion to the Cellular Biology title. The complexities of human physiology are made much clearer through the bright graphics and intelligently coordinated text boxes and glossaries that are...

ANAT - Anatomy
ANAT 14
All Professors
Permachart - Marketing Reference Guide: Levator Veli Palatini, Orbicularis Oculi Muscle, Scalene Muscles

Muscular System: pe rm ac ha rts MT Head & Torso 2nd EDITION ...

ANAT - Anatomy
ANAT 14
All Professors
ANAT - Anatomy
ANAT 14
All Professors
ANAT - Anatomy
ANAT 14
All Professors
Permachart - Marketing Reference Guide: Heart Valve, Inferior Vena Cava, Pulmonary Valve

permacharts TM Cardiovascular Physiology 2nd EDITION HEART STRUCTURE & FUNCTION ...

ANAT - Anatomy
ANAT 14
All Professors
ANAT - Anatomy
ANAT 14
All Professors
Permachart - Marketing Reference Guide: Meiosis, Nuclear Membrane, Nuclear Pore

l e a r n • r e f e r e n c e • r e v i e w permacharts TM CCellular Biology BIOLOGY BASICS C...

ANAT - Anatomy
ANAT 14
All Professors
Cellular Respiration - Reference Guides

The specific aspects of cellular respiration are explained in this helpful Guide. The fundamental processes such as the electron transport chain, proton pumps, ATP synthetase, and glycolysis are each described with helpful...

ANAT - Anatomy
ANAT 14
All Professors
Permachart - Marketing Reference Guide: Submandibular Duct, Parotid Duct, Palatine Tonsil

pe rm a ch a rtsMT DDigestive System 2nd EDITION Fi...

ANAT - Anatomy
ANAT 14
All Professors
Permachart - Marketing Reference Guide: Antigen-Presenting Cell, Memory T Cell, Clonal Deletion

permacharts TM IImmunology 2nd EDITION G ENERAL INFORMATION - AN OVERVIEW ...

ANAT - Anatomy
ANAT 14
All Professors
Permachart - Marketing Reference Guide: Superior Frontal Sulcus, Inferior Parietal Lobule, Superior Frontal Gyrus

p erm ac hartsMT Brain 2nd EDITION FIGURE 1: GROSS ANATOMY (LATERAL VIEW) ...

ANAT - Anatomy
ANAT 173
All Professors
Permachart - Marketing Reference Guide: Superficial Palmar Arch, Costocervical Trunk, Thyrocervical Trunk

p erm a ch ar tsMT CCirculatory System 2nd EDITION Figure...

Biology
BI 361
All Professors

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