BCMB30004 Lecture Notes - Lecture 11: Tubulin, Microtubule, Futile Cycle

• School: University of Melbourne
• Department: Biochemistry and Molecular Biology
• Course: BCMB30004
• Professor: Professor Cheng

Document Summary

* o-glcnac is a carbohydrate or a form of sugar. * at least a 1000 different proteins that we recognise are modified by this sugar molecule (o- * almost all proteins that seem to be phosphorylated also have o-glcnac. * o-glcnacylation results in the formation of intracellular proteins which forms part of their regulation. * this type of modification is related to glucose metabolism and so there has been an interest on how these sorts of events might be related to different disease types, especially metabolic disease e. g. dabetes, cancer cell biology. * o-glcnacylation is the additio(cid:374) of the (cid:373)o(cid:374)osaccharide -d-n-acetylglucosamine to hydroxyl (oh) containing residues (ser or thr) of proteins =o-li(cid:374)ked -n-glucosamine (o-glcnac). * a single sugar modification so there is only a single transfer of a single monosaccharide (no other further modifications) * -d-n-acetylglucosamine has 6 carbons 5 in the ring and one sticking out.