BCMB30004 Lecture Notes - Lecture 12: Mammalian Genome, Ube2I, Prostate Cancer

• School: University of Melbourne
• Department: Biochemistry and Molecular Biology
• Course: BCMB30004
• Professor: Professor Cheng

Document Summary

This is quite different to phosphate because phosphate it is very small and charged. * ubiquitination requires sequential action of 3 enzymes. * ubiquitin covalently bound specific residues of the targeted protein - commonly this is via the last amino acid of ubiquitin (gly 76) and a lys of the substrate protein (via an isopeptide bond). Can impact protein degradation (via proteasome), intracellular localisation of the targeted protein and protein-protein interactions. * sumo & ubiquitin share close structural similarities. So, when looking at ubiquitin, sumo 1 & sumo2/3 at a structural level, there are a lot of similarities in how these structures are organised the(cid:455) ha(cid:448)e a (cid:272)o(cid:373)(cid:373)o(cid:374) heli(cid:454) (cid:894)sho(cid:449)(cid:374) i(cid:374) g(cid:396)ee(cid:374)(cid:895) a(cid:374)d. * sumo is not a single protein product in the genome. In fact, the mammalian genome has 4 genes that encode sumo in the same way that there are multiple genes that encode ubiquitin in the human genome.