BCMB30004 Lecture Notes - Lecture 19: Phosphatidylinositol, Permease, Cell Membrane

• School: University of Melbourne
• Department: Biochemistry and Molecular Biology
• Course: BCMB30004
• Professor: Professor Cheng

Document Summary

* this involves a complex and it is a class 3 pi3k (vps34: phosphatidylinositol 3-phosphate) and this adds a phosphate to c-3 of the inositol ring. Note: in the induction complex there is a class 1 pi3k. * the other protein that is important in terms of the nucleation complex is beclin 1. * the nucleation complex/vps34 generates pip3 and this accumulation of pip3 enables the recruitment of atg proteins to the site of autophagosomal proteins that start initiating the formation of the autophagosome and this occurs at membranes inside the cell. So, there is an addition of a phosphate to c-3 position of the inositol ring. * the(cid:396)e is o(cid:374)l(cid:455) o(cid:374)e fa(cid:373)il(cid:455) (cid:373)e(cid:373)(cid:271)e(cid:396) i(cid:374) the (cid:272)lass (cid:1007) pi(cid:1007)k a(cid:374)d that"s vps(cid:1007)(cid:1008). * unlike the class 1 and class 2 pi3k, the class 3 pi3k/vps34 is active on intracellular membranes whereas the others are active on the plasma membrane.