BIOL10003 Lecture 11: New Control Methods for Pests and Diseases
21 Jul 2018
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Document Summary
Problems of more food from less area, denser populations. Anticipate climate change effects e. g. increase in malaria in australia. Must be toxic to the pest / parasite. Must be harmless to us (and domestic animals) So it must target some metabolic difference e. g. bacterial membranes differ from eukaryotes. Harder if the parasite is more like us. Understanding molecular action of current antibiotics can aid rational drug design. Most antibiotics target the bacterial ribosome (code genes and make proteins) Structure of ribosome recently revealed through x-ray crystallography. Prof ada yonath - won nobel prize for chemistry for this. Now drugs can be designed to attack it, or even perhaps in specific bacteria. It goes into erythrocyte (rbc of which malaria hides in). Inside plasmodium, there is a vacuole where the digestion of heme occurs. That"s where chloroquin takes it hazards effect, where it has much lower ph than outside.
