BIOL30001 Lecture Notes - Lecture 24: Persistent Organic Pollutant, Endocrine Disruptor, Estrogen
16 Oct 2018
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An exogenous agent that interferes with synthesis, secretion, transport, binding and action or elimination of natural hormones in the body which are responsible for the maintenance of homeostasis, reproduction, development and/or behaviour. Can be a natural chemical (phytochemical, plants) or synthetic chemical (xenochemical) Where are edcs found: plants soy, hops, clover; genistein, human-made plastics, drugs, household products, industrial chemicals, pesticides, animal oil & fat bioaccumulation. Mainly oestrogenic and anti-androgenic actions: pesticides, herbicides and insecticides, organochlorines, organophosphates, pyrethroids e. g. ddt/dde (used against malaria, banned. 1972s), atrazine: often chemical mixtures oestrogenic, anti-oestrogenic, androgenic, anti-androgenic actions. Pathways: oestrogenic des, bpa, methoxychlor, androgenic dde, vinclozolin. Steroid receptors (oestrogen and androgen) and have independent e ects not fully understood. Concentrations required normal hormones (nm or pm), edcs (pm to fm) elicit e ects at much lower doses. Hpg axis endocrine disruptors can a ect many stages of the axis via various target tissues:
