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Class Notes (1,030,099)
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BIOM20001 (134)

Class Notes for BIOM20001 at University of Melbourne

Molecular and Cellular Biomedicine

BIOM20001 Lecture Notes - Lecture 66: Lymph Node, Gallbladder Cancer, Malignancy
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Chronic inflammation:at sites of chronic inflammationwe get higher incidence of cancer Virchow (1863) proposed that cancer develops at sites of chronic inflammation The potential relationships between cancer and inflammati...

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BIOM20001 Lecture 66: 66-67 Neoplasia A
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6667 Neoplasia Thursday, 15 May 2014 10:31 PM Growth Disorders Increased Cell Growth Neoplasia Malignancy Uncontrolledsustainable,rapid cell growth without extracellular signalsligandsGFs Hypertrophy: increased size of ce...

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BIOM20001 Lecture Notes - Lecture 64: Elastin, Cell Adhesion Molecule, Apoptosis
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64 Wound Healing and Repair Thursday, 15 May 2014 10:31 PM Resolution, healing, scarring or chronic inflammation Healing Regeneration:tissue composedof cells and proliferative capacity AND underlying structure of the tissu...

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BIOM20001 Lecture Notes - Lecture 65: Epithelium, Endothelium, Fibroblast
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Ingest and eliminate microbes and dead tissues Initiate the process of tissue repair Display antigens to T-lymphocytesand respond to signals from T cells Die or wander off in the absence of inflammat...

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BIOM20001 Lecture Notes - Lecture 64: Blood Vessel, Zebrafish, Collagen
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Liver Regeneration occurs following mostinjury Resectionor cell death (necrosis or apoptosis) e.g. can surgically removal (60). Will be restored in 46 weeks. If you removea lobe the remaining lobes proliferate to replace ...

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BIOM20001 Lecture 67: 66-67 Neoplasia C
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The binding of a ligand to receptor triggers series of events by which extracellular signals are transduced, resulting in changes in gene expression Receptorslacking intrinsic tyrosine kinase activity transmit extracellula...

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BIOM20001 Lecture Notes - Lecture 64: Proteoglycan, Serous Membrane, Collagen
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Cutaneous wound healing Involves epithelial regeneration and connective tissue scar (repair) 2 types of wounds severity leading to: Healing by first intention: small disruption Focal disrup...

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BIOM20001 Lecture Notes - Lecture 65: Peptic Ulcer, Atherosclerosis, Macrophage
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65 Chronic inflammation Thursday, 15 May 2014 10:31 PM Chronic inflammation Prolonged inflammation(weeks, months, years) Persistent stimulus - cycle of macrophagesand lymphocytes - inflammation,injury (to cell...

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BIOM20001 Lecture Notes - Lecture 65: Sarcoidosis, Necrosis, Neoplasm
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Bronchiectasis persistent infection Asbestosis exogenous toxin Ulcerative colitis inappropriate immune response Chronic peptic ulcer persistent inflammation Chronic cholecystitis recurrent acute cholecystitis Rheumatoid ar...

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BIOM20001 Lecture Notes - Lecture 61: Meninges, Vasodilation, Pus
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AA metablitesproduced by leukocyteswhen they enter tissue Inhibit neutrophil: chemotaxisand adhesion Negative regulators of leukotrienes Acute inflammat...

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BIOM20001 Lecture Notes - Lecture 62: Tuberculosis, Immunoglobulin M, Autoantibody
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deposited in tissue (basement membranesof blood vessels,kidney, joints due to ultrafiltration in these parts) induce inflammatoryreaction Disease is systemicwhen immune complexesare formed in the circula...

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BIOM20001 Lecture Notes - Lecture 62: Type Iii Hypersensitivity, Vasodilation, Apitoxin
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62-63 Immune mediated injury Thursday, 15 May 2014 10:31 PM Normal immune response Immunity:provides protectionagainst infection; mediated by cells of the immune response Innate ...

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BIOM20001 Lecture Notes - Lecture 59: Urinary Tract Infection, Bronchitis, Necrosis
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(Mitochondrial)Intrinsic pathway (signal inside cell) Balance between pro and anti-apoptotic proteins(of the Bcl-2 family) that determines whether it underg...

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BIOM20001 Lecture Notes - Lecture 60: White Blood Cell, Neutrophil, Extracellular Fluid
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60 Acute Inflammation 1 Thursday, 15 May 2014 10:31 PM Inflammation A protectiveresponse intended to eliminate the cause and consequence of cell injury (e.g. micro-organism/e.g.cause: paper cut, consequence:...

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BIOM20001 Lecture Notes - Lecture 61: C3B, Respiratory Burst, Gram-Negative Bacteria
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61 Acute Inflammation 2 Tuesday, May 20, 2014 11:01 PM Steps of inflammation:Recognition > recruitment > removal> regulation > resolution Recognition:PAMP and DAMP (injury) recognised by PRR Recruitment Vascular Vasodilati...

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