BIOM20001 Lecture Notes - Lecture 64: Elastin, Cell Adhesion Molecule, Apoptosis
Document Summary
Regeneration: tissue composed of cells and proliferative capacity and underlying structure of the tissue has not been too severely damaged. Repair by scar formation: tissues composed of cells with limited or no proliferative capacity. Or tissue does have regenerative capacity but the underlying structure of the host tissue is lost - scaffolding lost so tissue cannot be replaced e. g. hypoxy to the brain - tissue not replaced. Mcb page 1 lost - scaffolding lost so tissue cannot be replaced e. g. hypoxy to the brain - tissue not replaced by neuron so scar forms. Propridium iodide detection of dna content in peripheral blood mononuclear cells (pbmc) by facs analysis. Cell has different amounts of dna depending on where it is in the cell cycle. This determines the strength of the signal we get. Less than one unit of dna represent apoptotic cells. (not examinable) Maturation of stem cells or proliferation of mature cells.
