BIOM30001 Lecture Notes - Lecture 36: Cannabinoid Receptor Type 1, Intraocular Pressure, Addiction
Document Summary
Thc (tetrahydratecannabinol)- reward signalling component of cannabis, reduced intra-ocular pressure, appetite stimulation. Street marijuana are bred under a uv light which can yield a very high thc contents but little cannabidiol as it is bred out. Cb1 r (cns) & cb2 r (immune) identified but more are likely to exist. Cb1 agonist: (thc) products: sativex, dronabinol for anorexia, wasting (aids) and nausea associated cancer (special access scheme) Cb1 antagonist: rimonabant appetite suppressant; anti-addictive; ?antipsychotic but adverse effects in trials. Figure: lifetime risk of death from an alcohol-related disease, by number of standard drinks per day, per 100 people with that drinking pattern, australia 2002. Clear dose response to exposure to alcohol through life. There is no safe level of drinking, but the risk is low around 1-2 drinks a day. Cancer is one of the top three killers of alcoholics (esp in people who get flushed/headaches) Intermittent drinking seems to be ok, but habitual drinking is a problem.
