CHEM10006 Lecture Notes - Lecture 29: Nucleophilic Substitution, The Boc Group, Carboxylic Acid

• School: University of Melbourne
• Department: Chemistry
• Course: CHEM10006
• Professor: Frances Separovic

Document Summary

Amino acids contain a basic amino group and an acidic carboxyl group. Some have neutral side chains, some are acid and amides. Know what disulfide bonds look like for the exam 2 cysteine residues linked together via a sulphur-sulphur bond. Know from the peptide which amino acid it is or from the name of the peptide, know the amino acid. Note: can stabilise negative and charges with resonance structures. Nature only builds proteins out of l-amino acids: L = nh3 on the left (can be r or s) Find overlap of peptides to assemble protein. Need to have only one nucleophile and carboxylic acid. This requires protecting the carboxylic acid of one of the amino acids and the amine of the other. Dcc (don"t use an acid cos that would deprotect n terminus instead of destroying protecting groups) need to activate oh. Alpha amino acids contain a basic amino group and an acidic carboxyl group.