FOOD20003 Lecture Notes - Lecture 29: Homocysteine, Anemia, Neural Tube Defect
28 Jun 2018
School
Department
Course
Professor
Amino acid metabolism:
converts tryptophan to
niacin or serotine
Urea metabolism
Decarboxylation of
histidine to form
histamine
Production of RBCs
Alcohol destroys the
vitamin
• Breakdown of
alcohol à
produces
acetaldehyde
which dislodges
PLP coenzyme
from its enzyme
• Once free, PLP
breaks down and
is excreted.
Toxicity
• Depression,
fatigue, irritability,
and headaches
• Numbness and
muscle weakness
• Inability to walk
• Convulsions, skin
lesions etc
Upper Limit:
50mg/day
Folate
(B9)
Also known as folic acid,
folacin, PGA
Involved in the synthesis
of DNA and thus the
formation of new cells
Folate (B6) and
cobalamin (B12) work in
concert
• The coenzyme TFH
(tetrahydrofolate)
and DHF
(dihydrofolate)
Fortified grains
Leafy green
vegetables
Legumes and
seeds
Liver
Easily destroyed
by heat
Deficiency
• Impairs cell
division and
protein synthesis
• Replacement of
RBCs and GI tract
cells affected
Most vulnerable to
interactions with
medications (i.e.
aspirin interferes
with body handling
of folate)
Neural tube defects
• Brain and spinal
cord develop
Document Summary
Amino acid metabolism: converts tryptophan to niacin or serotine. Involved in the synthesis of dna and thus the formation of new cells. Folate (b6) and cobalamin (b12) work in concert: the coenzyme tfh (tetrahydrofolate) and dhf (dihydrofolate) Alcohol destroys the vitamin: breakdown of alcohol produces acetaldehyde which dislodges. Plp coenzyme from its enzyme: once free, plp breaks down and is excreted. Toxicity: depression, fatigue, irritability, and headaches, numbness and muscle weakness, inability to walk, convulsions, skin lesions etc. Deficiency: impairs cell division and protein synthesis, replacement of. Most vulnerable to interactions with medications (i. e. aspirin interferes with body handling of folate) Neural tube defects: brain and spinal cord develop requires activation by vitamin b12. Fortified cereals from the neural tube: defects in early formation result in cns disorders and death, pregnant women should consider rich-folate diets. Alcohol and folate deficiency: alcohol damage the gi tract epithelial cells reduces reabsorption of folic acid, decreasing folic acid leads to deterioration of.
