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MIIM20001 (21)

Class Notes for MIIM20001 at University of Melbourne

Principles of Microbiology & Immunology

MIIM20001 Lecture Notes - Lecture 35: Dengue Virus, Innate Immune System, Japanese Encephalitis
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Lecture 35- Flipped Classroom Why cant we generate effective vaccines to some viruses? Dengue Virus Belongs to Flavivirus genus of the Flaviviridae family Other Flaviviruses: Yellow Fever, Japanese Ence...

Microbiology and Immunology
MIIM20001
A/Prof Jason Mackenzie
MIIM20001 Lecture Notes - Lecture 34: Adaptive Immune System, Smallpox, Affinity Maturation
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Vaccines I Vaccines: Aims: Elicit an immune response that will prevent or limit disease upon encounter with the target organism Outcomes: Prevention of disease Prevention of transmission ...

Microbiology and Immunology
MIIM20001
A/Prof Jason Mackenzie
MIIM20001 Lecture 33: Lecture 33
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Lecture 33 Genetic Manipulation of Bacteria Viruses Recombinant DNA technology Biotechnology Is the manipulation of organisms or their components to make useful products Has been used for thousands of years to o Make bre...

Microbiology and Immunology
MIIM20001
A/Prof Jason Mackenzie
MIIM20001 Lecture 31: Lecture 31
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Lecture 31: Control of Virus infections Viral Pandemics CDC Estimates of (strain A) AH1N1 pandemic from April 2009 April 10, 2010 Between 43 million and 89 million cases of 2009 H1N1 occurred Between about 195,000 and 403,...

Microbiology and Immunology
MIIM20001
A/Prof Jason Mackenzie
MIIM20001 Lecture Notes - Lecture 30: Viral Pathogenesis, Arthropod, Macrophage
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Lecture 30: Viral Pathogenesis Viral Pathogenesis: At the level of the host anima To cause infection viruses must: Gain entry to body Multiply and spread (locally or systemically) Target appropriate organ To be maintained ...

Microbiology and Immunology
MIIM20001
A/Prof Jason Mackenzie
MIIM20001 Lecture Notes - Lecture 29: Rna Virus, Viral Envelope, Lipid Bilayer Fusion
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Lecture 29: Virology II Stages of the virus replication cycle 1. Attachment - Some viruses only want to ...

Microbiology and Immunology
MIIM20001
A/Prof Jason Mackenzie
MIIM20001 Lecture Notes - Lecture 27: Penicillium Chrysogenum, Safe Operating Area, Bacteriostatic Agent
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Lecture 27 Antibiotic control of Bacterial infections Selective toxicity Bacteria (antibiotics) Viruses (antivirals) - Mostly produced by other microorganisms, some synthetic compounds - Warfare that ...

Microbiology and Immunology
MIIM20001
A/Prof Jason Mackenzie
MIIM20001 Lecture 26: Lecture 26
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Lecture 26 Damage to the Host 5. Cause Damage to the Host Damage the host (disease) Direct Exotoxins Endotoxin (bacterial LPS) Indirect Immunopathology Direct: Bacterial exotoxins Exotoxin = secreted toxin Usually protein ...

Microbiology and Immunology
MIIM20001
A/Prof Jason Mackenzie
MIIM20001 Lecture 25: Lecture 25
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Lecture 25 Evasion of Immune defences To cause disease most pathogens must: 1. Enter the body 2. Colonise the host 3. Evade host defences 4. Multiply disseminate 5. Cause damage to host Evasion of host defences: Soluble f...

Microbiology and Immunology
MIIM20001
A/Prof Jason Mackenzie
MIIM20001 Lecture Notes - Lecture 24: Human Microbiota, Diabetes Mellitus Type 2, Mucous Membrane
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Lecture 24: Bacterial Pathogenesis Bacterial Pathogenesis The mechanisms by which bacteria cause disease Target humans, animals and plants 538 known bacterial pathogens No longer overwhelming thr...

Microbiology and Immunology
MIIM20001
A/Prof Jason Mackenzie
MIIM20001 Lecture Notes - Lecture 20: Dna Gyrase, Bacillus Cereus, Antimicrobial Resistance
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Lecture 20 Microbial Genetics The Central Dogma Extra cookbooks Not possible for a bacterial genome to contain every gene that might be useful - Metabolic burden if bacterial...

Microbiology and Immunology
MIIM20001
A/Prof Jason Mackenzie
MIIM20001 Lecture 19: Lecture 19 – Microbial Genetics
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Lecture 19 Microbial Genetics Gene Structure: Definition of a gene: Polynucleotide sequence that codes for a functional product Protein, tRNA, rRNA, sRNA How are genes recognised? What makes a gene? Bacterial gene struct...

Microbiology and Immunology
MIIM20001
A/Prof Jason Mackenzie
MIIM20001 Lecture Notes - Lecture 16: Ester, Uracil, Thymine
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Lecture 16- Microbial Genetics The Flow of Genetic Information Central dogma: The pathway from DNA to RNA to protein gene expression Conserved in all cellular forms of life DNA RNA = transcri...

Microbiology and Immunology
MIIM20001
A/Prof Jason Mackenzie
MIIM20001 Lecture Notes - Lecture 14: Siderophore, Fluorophore, Atp-Binding Cassette Transporter
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Lecture 14 Parasites and Fungi I Uptake of Nutrients Microbes take up various dissolved molecules using specific uptake mechanism - Specific uptake mechanisms required because nutrients: ...

Microbiology and Immunology
MIIM20001
A/Prof Jason Mackenzie
MIIM20001 Lecture 13: Lecture 13 – Bacteria Metabolism
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Lecture 13 Bacteria Metabolism Growing Microbes To study microbes it is necessary to grow them How do we grow microbes? Provide them with their required: Nutritional components Environmental components Nutritional compon...

Microbiology and Immunology
MIIM20001
A/Prof Jason Mackenzie

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