MIIM20001 Lecture Notes - Lecture 14: Siderophore, Fluorophore, Atp-Binding Cassette Transporter

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5 Aug 2018

School

University of Melbourne

Department

Microbiology and Immunology

Course

MIIM20001

Professor

A/Prof Jason Mackenzie

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Document Summary

Uptake of nutrients: microbes take up various dissolved molecules using specific uptake mechanism. Multiple mechanisms to transport same molecule in case something: several different transport mechanisms used nutrients goes wrong in one mechanism. Sidephores ( iron uptake: bacteria & microbes secrete from cell into surroundings to locate nutrients and bring them back into cell. Iron uptake: almost all microbes require iron. Need right irons to be metabolically active (fe3+) and its derivatives: but iron uptake is difficult given the extreme insolubility of ferric iron. Thus iron is a limiting nutrient in the environments of many: maintaining iron supply is important to many microbes that microbes. Many bacteria and fungi secrete siderophores they may have >1 uptake route to ensure adequate uptake. Secreted when iron is scarce in medium. Low molecular weight organic molecules: bind fe3+ iron and supply it to cell, forming an iron-siderophore complex. Siderophores: complex then binds to siderophore-receptor protein on cell surface.

Related Questions

Question 1

Plasma membranes are selectively permeable. This means that

	A.	glucose cannot enter the cell.
	B.	the plasma membrane allows some substances to enter or leave a cell more easily than others.
	C.	plasma membranes must be very thick.

Question 2

Oxygen molecules O₂ crosse a plasma membrane by

	A.	passive transport
	B.	osmosis
	C.	active transport

Question 3

Facilitated diffusion across a biological membrane requires ________ and moves a substance ________ its concentration gradient.

		A. energy and channel proteins; against (up)
		B. transport proteins that make channels ; down
		C. energy ; down

Question 4

When two aqueous solutions that differ in solute concentration are placed on either side of a semipermeable membrane and osmosis is allowed to take place, the water will

		A. move to the side with lower water concentration
	B.	move to the side with higher water concentration
	C.	move to the side with lower solute concentration

Question 5

Kinetic energy differs from chemical energy in that

	A.	chemical energy is a particular form of kinetic energy.
	B.	kinetic energy is the energy of a moving object, whereas chemical energy is the potential energy of molecules.
	C.	kinetic energy is stored energy that has the potential to do work, and chemical energy is the energy of movement.

Question 6

When a cell uses chemical energy to perform work, it uses the energy released from a(n) ________ reaction to drive a(n) ________ reaction.

	A.	exergonic; endergonic
	B.	endergonic; exergonic
	C.	spontaneous; exergonic

Question 7

When an enzyme catalyzes a reaction

		A. it raises the activation energy of the reaction.
		B. it lowers the activation energy of the reaction.
		C. it is used once and discarded.

Question 8

Which of the following statements regarding enzyme function is false?

		A. An enzyme's function depends on its three-dimensional shape.
		B. Enzymes are very specific for their substrates.
		C. Enzymes are used up when they catalyze a chemical reaction so must be synthesized for each new chemical reaction

________30. If you are investigating the inner structure of a new cell and see that it has a significantly larger amount of RER than other cells. You would conclude the cell does a great deal of____?
A. ATP synthesis

B. protein synthesis
C. DNA synthesis
D. active transport
E. polysaccharide hydrolysis

________31. If a cell comes in contact with a toxic substance such as H2O2, it could survive as long as it has a ___ to digest it.
A. DNA
B. peroxisome

C. mitochondria
D. phospholipids
E. intermediate filaments

________32. Some cells have structures to help them withstand osmotic pressure. For example,
A. Plant cells due to their walls
B. Animal cells due to the sodium/potassium pumps

C. Bacterial cell due to their swimming

D. Viruses due to their protein coats

________33. Evolution occurs only as a cell ____.

A. They undergo mitosis
B. Change in their gene pool
C. They move from one habitat to another

D. They begin to eat different foods

________34. Ribosomes are produced in the

A. nucleoli.
B. chromatin.
C. nuclear envelopes.

D. Golgi complex. E. cisternae.

________35. Algae are often green, but there are red and brown species also. What accounts for this difference in color?
A. The chlorophyll of chloroplasts
B. The pigments in other plastids

C. The presence of a mitochondria
D. The accumulation of cellular wastes

________36. The chloroplast and other like prokaryotes have which of the following that helps with photosynthesis?
A. They live in water based environments
B. They have chloroplasts in their cytoplasm

C. Change color in the dark vs. the sun
D. They have photoreceptor proteins in their membranes or mesosomes.

________37. Located in the membrane, we see a set of proteins called receptors that only connect with or bind to specific substances. This is called __.
A. ligand specificity.
B. hormone selectivity.

C. cell tonicity.
D. water saturation. E. signal resolution.

________38. Of the following statements, we could say that ___ is false.
A. All organisms are composed of cells and cell products.
B. An organism's structure and all of its functions are due to the activities of cells.
C. The cellular organelles are the simplest structural and functional unit of life.
D. Cells come from preexisting cells.
E. Cells are made from nonliving components including the nucleus, cell membrane and cytoplasm.

________39. If it is really true that our cells are the smallest anatomical unit that meets all of the properties of life, then which of the following could imply otherwise?
A. vacuoles
B. centrioles

C. Golgi apparatus
D. mitochondria
E. endoplasmic reticulum

________40. Oxygen is an absolute need for animal and plant cells alike due to the ___.

A. RER
B. Mitochondria
C. Lysosomes

D. DNA

________41. In a plasma membrane, we expect to see the carb/protein structures to extend into the ___, but the secondary messengers to move within the __.
A. extracellular fluid; cytosol
B. cytosol; extracellular fluid

C. intracellular fluid; cytosol

D. cytosol; intracellular fluid

E. extracellular fluid; plasma

________42. Bacteria are found in all of the following habitats:

A. Caves
B. Oceans
C. Animals

D. Everywhere on Earth

________43. Two solutions are separated by a selectively permeable membrane. Solution A has a higher concentration of an impermeable solute compared to solution B. Which of the following do you expect would happen?
A. solute will move from solution A to solution B

B. solute will move from solution B to solution A

C. water will more from solution A to solution B

D. water will move from solution B to solution A E. no movement of solute or water will occur

________44. In the kidney, we notice that almost all of the cells involved in the production of urine have high concentrations of the Na+/K+ pump. Which typically works to push Na+ ___ its concentration gradient by using ___.
A. up; active transport

B. up; facilitated transport
C. up; cotransport
D. down; active transport
E. down; facilitated transport

________45. In the charts of a patient recently admitted to the hospital noted that he was taking a medication called lithium and high doses of calcium supplements. Given this, we would expect the patientâs liver to have a higher than normal amount of __ to purify out the lithium and calcium.

A. lysosomes.
B. centrosomes.
C. mitochondria.
D. peroxisomes.
E. rough endoplasmic reticulum.

________46. We have long observed that our neural cells in the brain cannot replicate or replace themselves due to the lack of ____.
A. produce ATP.
B. divide.

C. produce enzymes.
D. secrete material across their plasma membrane E. conduct electrical signals.

________47. An organismâs structure and function is ultimately due to the structure and function of itâs __.
A. Organs
B. Tissues

C. Cells

D. Nuclei

1) Which of the following is a component of a vertebrate kidney? (Select all correct choices.)

		glomerulus
		Bowman's capsule
		renal tubules
		collecting ducts
		Malphigian tubules

In organisms, the ability to control osmosis depends on the properties of the plasma membranes of individual cells. Based on their ability to permit the free movement of water and some solutes, these membranes are best described as: (select all correct choices)

		impermeable.
		permeable.
		semipermeable.
		diffusible.
		impervious.

3)I selected cortex; inner medulla, it was wrong.

The loops of Henle create a concentration gradient in the interstitial fluid surrounding the loop, with the concentration highest in the ____________ and lowest in the ____________ of the kidney.

		inner medulla; cortex
		outer medulla; inner medulla
		outer medulla; cortex
		cortex; inner medulla
		cortex; outer medulla

The main solutes in the filtrate as it enters the distal convoluted tubule are: (select all correct choices)

		urea.
		electrolytes.
		other wastes.
		amino acids.
		nucleotides.

5) Ensure all correct choices are selected, for this question I only selected osmosis and it was wrong,

Water moves by: (select all correct choices)

		random molecular motion.
		active transport.
		passive transport.
		osmosis.
		facilitated diffusion

Compared to sexual reproduction, asexual reproduction: (select all correct choices)

	requires less investment in attracting mates.
	allows much more rapid population growth.
	is rarely found as the sole mechanism of reproduction.
	results in the production of genetically identical cells or individuals.
	involves meiosis and fertilization as core processes.

A key difference between hormonal regulation of the reproductive systems of males and females is that:

	LH and FSH are released only in females.
	LH and FSH are released only in males.
	LH and FSH are released cyclically in females but nearly continuously in males.
	LH is released in males and FSH is released in females.
	LH is released continuously in males and FSH is released cyclically in females.

True or false: In response to LH and FSH, ovaries secrete estrogen and progesterone.

	true
	false

During the luteal phase of the menstrual cycle, if the oocyte is not fertilized, a number of events occur which are listed below. Select the answer that places the events in the correct chronological order.

Events:
1. the lining of the uterus is shed
2. the corpus luteum secretes progesterone
3. follicle cells are converted to the corpus luteum
4. the corpus luteum degenerates
5. estrogen and progesterone levels fall

	3, 2, 4, 5, 1
	1, 2, 3, 4, 5
	2, 4, 3, 1, 5
	4, 3, 2, 1, 5
	5, 2, 3, 4, 1

10)

If an antibody is missing its Fc fragment, what would happen if this antibody encounters its target antigen in the bloodstream? Select all correct choices.

	The antibody would be able to bind the antigen at a specific epitope.
	The antibody would be able to bind the antigen, but not at an epitope site.
	The antibody would not be able to bind to the antigen.
	The antibody would be able to activate components of the complement system.
	The antibody would not be able to activate components of the complement system.

11)

If an individual carries a mutation that results in a complete lack of MHC class I proteins, how would the individualâs immune response be affected? Select all correct choices.

	Memory cell antibodies would not be able to attach to antigen epitopes.
	Cytotoxic T cells would not be able to target (and destroy) infected cells.
	Helper T cells would not be able to interact with antigen-presenting cells.
	Plasma cell antibodies would not be able to attach to antigen epitopes.

12)

Which of the following statements is true regarding T cell receptors? Select all correct choices.

	They recognize antigen-MHC complexes.
	They contain variable and constant regions.
	They are composed of two heavy (H) chains and two light (L) chains.
	They are formed by the rearrangement of V, J, C, and D gene segments.
	They can be found in the bloodstream independent of T cells.

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MIIM20001 Lecture Notes - Lecture 14: Siderophore, Fluorophore, Atp-Binding Cassette Transporter

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