MIIM20002 Lecture Notes - Lecture 23: Plasmid, Keratin, Dorsal Root Ganglion

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Display many of the features typical of stis. The cells that are the site of persistence. The basis for persistence - depends on the (cid:396)epli(cid:272)atio(cid:374) st(cid:396)ateg(cid:455) (cid:894)vi(cid:396)us ofte(cid:374) (cid:862)hides(cid:863)(cid:895) a(cid:374)d the ability to avoid the immune response (i. e. ctls and antibodies) Encode a large array of proteins (enzymes, structural proteins, immune evasion) All members can remain latent in the host. Other members of the herpesviridae family cause chicken pox (vzv), glandular fever (ebv, cmv), roseola infantum (hhv-(cid:1010)(cid:895), kaposi"s sa(cid:396)(cid:272)o(cid:373)a (cid:894)hhv-8). Very common (hsv nearly regarded as part of the normal flora) In latent stage dna forms a closed circle (episome) Envelope makes it fragile in environment, adapted to transfer through body fluids associated with sexual activity. Tegument proteins: a layer of viral proteins carried under the envelope. Distinguish between hsv-1 and hsv-2 by serological tests (detect antigens) or pcr (detects differences in genes between hsv-1 and hsv-2) Generally hsv-1 causes cold sores on lips and hsv-2 causes genital herpes.

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