MIIM20002 Lecture Notes - Lecture 31: Dengue Virus, Japanese Encephalitis, Flavivirus

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Dengue virus belongs to the flavivirus genus of flaviviridae family. Other flaviviruses include: yellow fever (have vaccine), japanese encephalitis (have vaccine) Other flaviviruses include: yellow fever (have vaccine), japanese encephalitis (have vaccine) and west nile virus (occasionally cause encephalitis) M is a cleavage product and a chaperone protein that helps virus get out of cells. Different genotypes within each serotype - may have different fitness phenotypes. Attach to receptors --> enters by endocytosis --> endosome acidified --> at low ph virus fuses with endosome. Microbes page 6 exits cell by golgi --> cleavage of chaperone protein prm --> mature virion with 90 homodimers on surface. Uncomplicated case: fever plus two or more of; Microbes page 7: fever plus two or more of, headache, myalgia, fatigue, retro- orbital pain, vomiting, anorexia, joint pain. In addition to these may get additional severe symptoms. Aedes aegypti: most important vector in endemic countries. Adults tend to rest on surfaces inside homes.

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