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PHRM30002 (9)

Class Notes for PHRM30002 at University of Melbourne

Drugs Affecting the Nervous System

PHRM30002 Lecture Notes - Lecture 10: Posterior Pituitary, Naloxone, Endorphins
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L10 Neuropeptides (NP) Summary - NP: small proteins or polypeptides with NT-like roles - Diverse roles o Pain and analgesia, sleep, emotion, feeding, learning and memory o Eg. Subs...

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PHRM30002 Lecture Notes - Lecture 4: Mesolimbic Pathway, Catechol-O-Methyl Transferase, Carbidopa
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L4 & 5 Catecholamines NA transmission - summary Neurotransmission 1. Synthesis/storage - DA as precursor of NA at the periphery - DA as a NT in CNS 2. Release - A...

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PHRM30002 Lecture Notes - Lecture 6: Esterase, Physostigmine, Cyclic Adenosine Monophosphate
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L6 & 7 ACh Summary Roles - Associated with o Arousal o Learning and memory o Motor control o Dependence - Drugs affecting CNS cholinergic tra...

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PHRM30002 Lecture Notes - Lecture 2: Ion Channel, Endocytosis, Reuptake
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L2 Nerves as Targets for Drug Action Nerve AP electrical signalling - Ion channel as a target - Ligand-gated ion channel Na+ channel K+ channel Ca2+ channel Cl- c...

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PHRM30002 Lecture Notes - Lecture 8: Analgesic, Hypnotic, Phenobarbital
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L8 & 9 GABA & Glutamate Summary - GABA Summary Glutamate - Major inhibitory NT (neurotransmitter) - AA...

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PHRM30002 Lecture Notes - Lecture 13: Astrocyte, Barrier Function, Kernicterus
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L13 Blood-CNS Barriers Summary - Blood-CNS barriers: multiple barriers Barrier Location (5) BBB Blood-Brain Barrier Cerebral endot...

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PHRM30002 Lecture Notes - Lecture 3: Hydrolysis, Chemical Synapse, Propranolol
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L3 Peripheral nerves - insights AR localisation and activation AR Target organs Function Agonists Antagonists Mechanism subtypes Blood vesse...

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PHRM30002 Lecture Notes - Lecture 1: Cholinesterase, Pharmacology, Afferent Nerve Fiber
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L1 Introduction to pharmacology Nervous Systems Organisation Nervous system Central Peripheral Autonomic (Involuntary) Sympathetic NA/ or AR Mood and BP ...

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PHRM30002 Lecture Notes - Lecture 12: Buspirone, Tryptophan, Sumatriptan
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L12 Serotonin (5HT) Structure 5HT has similar structure with ERG, DHE and LSD Roles Central and peripheral effects Biosynthesis and metabolism Tryptophan 5OHTryptophan 5OHTryptamine(5HT) [serotonin] Tryptophan Lamino aci...

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